TY - JOUR
T1 - Uptake of advanced glycation end products by proximal tubule epithelial cells via macropinocytosis
AU - Gallicchio, Marisa A
AU - Bach, Leon Ashley
PY - 2013
Y1 - 2013
N2 - Abstract
Chronic hyperglycaemia during diabetes leads to non-enzymatic glycation of proteins to form advanced glycation end products (AGEs) that contribute to nephropathy. We describe AGE uptake in LLC-PK1 and HK2 proximal tubule cell lines by macropinocytosis, a non-specific, endocytic mechanism. AGE-BSA induced dorsal circular actin ruffles and amiloride-sensitive dextran-TRITC uptake, significantly increased AGE-BSA-FITC uptake (167?20 vs BSA control, p
AB - Abstract
Chronic hyperglycaemia during diabetes leads to non-enzymatic glycation of proteins to form advanced glycation end products (AGEs) that contribute to nephropathy. We describe AGE uptake in LLC-PK1 and HK2 proximal tubule cell lines by macropinocytosis, a non-specific, endocytic mechanism. AGE-BSA induced dorsal circular actin ruffles and amiloride-sensitive dextran-TRITC uptake, significantly increased AGE-BSA-FITC uptake (167?20 vs BSA control, p
UR - http://www.ncbi.nlm.nih.gov/pubmed/23747564
U2 - 10.1016/j.bbamcr.2013.05.024
DO - 10.1016/j.bbamcr.2013.05.024
M3 - Article
SN - 0167-4889
VL - 1833
SP - 2922
EP - 2932
JO - BBA Molecular Cell Research
JF - BBA Molecular Cell Research
IS - 12
ER -
