Uptake of advanced glycation end products by proximal tubule epithelial cells via macropinocytosis

Marisa A Gallicchio, Leon Ashley Bach

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Abstract Chronic hyperglycaemia during diabetes leads to non-enzymatic glycation of proteins to form advanced glycation end products (AGEs) that contribute to nephropathy. We describe AGE uptake in LLC-PK1 and HK2 proximal tubule cell lines by macropinocytosis, a non-specific, endocytic mechanism. AGE-BSA induced dorsal circular actin ruffles and amiloride-sensitive dextran-TRITC uptake, significantly increased AGE-BSA-FITC uptake (167?20 vs BSA control, p
Original languageEnglish
Pages (from-to)2922 - 2932
Number of pages11
JournalBBA Molecular Cell Research
Issue number12
Publication statusPublished - 2013

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