Upregulation of circulating components of the alternative renin-angiotensin system in inflammatory bowel disease: A pilot study

Mayur Garg, Louise M Burrell, Elena Velkoska, Karen Griggs, Peter W Angus, Peter Raymond Gibson, John S Lubel

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17 Citations (Scopus)

Abstract

Introduction: The relationship between intestinal inflammation and circulating components of the renin-angiotensin system (RAS) is poorly understood. Materials and methods: Demographic and clinical data were obtained from healthy controls and patients with inflammatory bowel disease (IBD). Plasma concentrations of the classical RAS components (angiotensin-converting enzyme (ACE) and angiotensin II (Ang II)) and alternative RAS components (ACE2 and angiotensin (1-7) (Ang (1-7))) were analysed by radioimmuno- and enzymatic assays. Systemic inflammation was assessed using serum C-reactive protein (CRP), white cell count, platelet count and albumin, and intestinal inflammation by faecal calprotectin. Results: Nineteen healthy controls (11 female; mean age 38 years, range 23-68), 19 patients with Crohn s disease (11 female; aged 45 years, range 23-76) and 15 patients with ulcerative colitis (6 female; aged 42 years, 26-64) were studied. Circulating classical RAS component levels were similar across the three groups, whereas ACE2 activity and Ang (1-7) concentrations were higher in patients with IBD compared to controls (ACE2: 21.5 vs 13.3 pmol/ml/min, p
Original languageEnglish
Pages (from-to)559 - 569
Number of pages11
JournalJournal of the Renin-Angiotensin-Aldosterone System
Volume16
Issue number3
DOIs
Publication statusPublished - 2015

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