Updated US and European Dose Recommendations for Intravenous Colistin: How Do They Perform?

Roger L Nation, Samira M. Garonzik, Jian Li, Visanu Thamlikitkul, Evangelos J. Giamarellos-Bourboulis, David L Paterson, John D. Turnidge, Alan Forrest, Fernanda P. Silveira

Research output: Contribution to journalArticleResearchpeer-review

132 Citations (Scopus)

Abstract

Background. The US Food and Drug Administration (FDA) and European Medicines Agency (EMA) have approved updated dose recommendations for intravenous colistin in patients with various degrees of renal function. We assessed the recommendations in relation to their ability to achieve clinically relevant plasma colistin concentrations. 

Methods. Pharmacokinetic data from 162 adult critically ill patients (creatinine clearance range, 5.4-211 mL/min) were used to determine the average steady-state plasma colistin concentration (Css,avg) that would be achieved if each patient received the FDA or EMA dose. Target attainment rates for FDA- and EMA-approved daily doses to achieve colistin Css,avg of ≥0.5, ≥1, ≥2, and ≥4 mg/L were determined for each creatinine clearance category (≥80 mL/min, 50 to <80 mL/min, 30 to <50 mL/min, and <30 mL/min). 

Results. For creatinine clearance <30 mL/min, 100% of patients receiving the EMA dose achieved a colistin Css,avg ≥1 mg/L, but the attainment rate was as low as 53.1% for patients receiving the FDA-approved dose. For colistin Css,avg ≥2 mg/L, the attainment rates were 87.5% with the EMA dose but only 6.3%-34.4% in patients receiving the FDA dose. Differences in attainment rates for a colistin Css,avg of ≥2 mg/L and ≥4 mg/L extended to patients with creatinine clearance 30 to <50 mL/min. For patients with creatinine clearance ≥80 mL/min, only approximately 65%-75% of patients achieved a colistin Css,avg of ≥1 mg/L with either set of recommendations. 

Conclusions. The study highlights important differences between the FDA- and EMA-approved dose recommendations and informs the setting of clinical breakpoints.

Original languageEnglish
Pages (from-to)552-558
Number of pages7
JournalClinical Infectious Diseases
Volume62
Issue number5
DOIs
Publication statusPublished - 1 Mar 2016

Keywords

  • Clinical breakpoints
  • Intravenous colistin
  • Plasma colistin concentrations achieved
  • Therapeutic implications
  • Updated FDA-and EMA-approved dosing suggestions

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