TY - JOUR
T1 - Update on ethanol induced oxidative stress in liver toxicity and the effects of pregnancy
AU - Subramaniyan, Vetriselvan
AU - Jegasothy, Ravindran
N1 - Publisher Copyright:
© 2019, Indian Journal of Public Health Research and Development. All rights reserved.
PY - 2019/8
Y1 - 2019/8
N2 - Background: Ethanol induced hepatotoxicity is one of the major problems worldwide and especially in developing countries. Alcohol is the most abused substance and affects the normal defense mechanisms. Methodology: Chronic consumption of alcohol can cause behavioral changes, oxidative stress and elevation of liver enzymes due to imbalance between the antioxidant and pro-oxidant systems. Continuous oxidative stress results in accumulation of fat in the liver, which can lead to fibrosis, cirrhosis and liver cancer. Pathogenesis of alcoholic liver disease has several mechanisms and progression not fully understood. Results: Prognosis of alcohol induced liver disease depends on the period of alcohol consumption, percentage and volume of alcohol, inflammatory effects, dietary habits and genetic linkage among others. Conclusion: This review mainly focuses on updates on alcohol induced oxidative stress, liver toxicity and the effects of pregnancy.
AB - Background: Ethanol induced hepatotoxicity is one of the major problems worldwide and especially in developing countries. Alcohol is the most abused substance and affects the normal defense mechanisms. Methodology: Chronic consumption of alcohol can cause behavioral changes, oxidative stress and elevation of liver enzymes due to imbalance between the antioxidant and pro-oxidant systems. Continuous oxidative stress results in accumulation of fat in the liver, which can lead to fibrosis, cirrhosis and liver cancer. Pathogenesis of alcoholic liver disease has several mechanisms and progression not fully understood. Results: Prognosis of alcohol induced liver disease depends on the period of alcohol consumption, percentage and volume of alcohol, inflammatory effects, dietary habits and genetic linkage among others. Conclusion: This review mainly focuses on updates on alcohol induced oxidative stress, liver toxicity and the effects of pregnancy.
KW - Alcohol
KW - Liver toxicity
KW - Oxidative stress
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85073720804&partnerID=8YFLogxK
U2 - 10.5958/0976-5506.2019.02124.7
DO - 10.5958/0976-5506.2019.02124.7
M3 - Article
AN - SCOPUS:85073720804
SN - 0976-0245
VL - 10
SP - 1873
EP - 1877
JO - Indian Journal of Public Health Research and Development
JF - Indian Journal of Public Health Research and Development
IS - 8
ER -
