TY - JOUR
T1 - Update about Oralair® as a treatment for grass pollen allergic rhinitis
AU - Klimek, L.
AU - Brehler, R.
AU - Mösges, R.
AU - Demoly, P.
AU - Mullol, J.
AU - Wang, D. Y.
AU - O’Hehir, R. E.
AU - Didier, A.
AU - Kopp, M.
AU - Bos, C.
AU - Karagiannis, E.
N1 - Funding Information:
L Klimek reports grants and/or personal fees from Allergopharma, MEDA/Mylan, HAL Allergie, ALK Abelló, LETI Pharma, Stallergenes, Quintiles, Sanofi, ASIT biotech, Lofarma, Allergy Therapeut., AstraZeneca, GSK, Inmunotk, outside the submitted work, and Membership: AeDA, DGHNO, Deutsche Akademie für Allergologie und klinische Immunologie, HNO-BV, GPA, EAACI. R Mösges reports personal fees and/or grants from Allergopharma, Allergy Therapeutics, Bencard, Leti, grants, Lofarma, Stallergenes, Optima, Friulchem, Hexal, Klosterfrau, FAES, Meda, Novartis, UCB, BitopAG, Hulka, Ursapharm, Menarini, Mundipharma, Pohl-Boskamp, Inmunotek, Hikma, Sandoz, Lek, Cassella, SanofiGenzyme, Engelhard, SmartPeakFlow, Strathos, outside the submitted work. R.Brehler reports personal fees from ALK, Allergopharma, Astra Zeneca, Bencard, Gesellschaft zur Förderung der Dermatologischen Forschung und Fortbildung e.V., Gesellschaft für Information und Organization mbH, GSK, HAL, Leti, Merck, Novartis, Oto-Rhino-Laryngologischer Verein, Pierre Fabre, Pohl Boskamp, Stallergenes, Thermo-Fischer; fees for clinical studies from Allergopharma, Bencard, Biotech Tools, Genentech, Leti, Novartis, Circassia. C Bos and E Karagiannis are employees of Stallergenes Greer. Alain Didier was principal investigator in the clinical development programme of Oralair. He declares he has received personal fees for consultancy services for ALK and grants for participation in clinical research projects with ALK outside the submitted work. RE O’Hehir and DY Wang report no potential conflicts of interest with respect to the research, authorship and/or publication of this article.
Funding Information:
The work was supported by the Stallergenes Greer. Medical writing support in manuscript development was provided by Iain O’Neill on behalf of Newmed Publishing Services, in accordance with Good Publication Practice (GPP3) guidelines, with an unrestricted grant by Stallergenes-Greer.
Publisher Copyright:
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - Sublingual immunotherapy (SLIT) is a well-tolerated, safe, and effective approach to treating allergic rhinitis (AR). Oralair® is a five-grass pollen SLIT tablet containing natural pollen allergens from five of the major grass species responsible for seasonal AR due to grass pollen allergy. Recommended use is in a pre-coseasonal regimen, starting daily treatment approximately 4 months before the start of the pollen season, with treatment then continued daily throughout the season; treatment should continue for 3–5 y. Clinical efficacy and safety of Oralair® in patients with grass pollen-induced AR has been demonstrated in a comprehensive clinical development program of randomized controlled trials. Effectiveness has been substantiated in subsequent observational studies with sustained efficacy following treatment cessation and a favorable level of adherence, quality of life, benefit, and satisfaction for the patients. Supportive evidence for a benefit in reducing the risk or delaying the development of allergic asthma is emerging.
AB - Sublingual immunotherapy (SLIT) is a well-tolerated, safe, and effective approach to treating allergic rhinitis (AR). Oralair® is a five-grass pollen SLIT tablet containing natural pollen allergens from five of the major grass species responsible for seasonal AR due to grass pollen allergy. Recommended use is in a pre-coseasonal regimen, starting daily treatment approximately 4 months before the start of the pollen season, with treatment then continued daily throughout the season; treatment should continue for 3–5 y. Clinical efficacy and safety of Oralair® in patients with grass pollen-induced AR has been demonstrated in a comprehensive clinical development program of randomized controlled trials. Effectiveness has been substantiated in subsequent observational studies with sustained efficacy following treatment cessation and a favorable level of adherence, quality of life, benefit, and satisfaction for the patients. Supportive evidence for a benefit in reducing the risk or delaying the development of allergic asthma is emerging.
KW - 5-Grass pollen tablet
KW - allergen immunotherapy
KW - allergic rhinoconjunctivitis
KW - asthma
KW - sublingual immunotherapy
UR - http://www.scopus.com/inward/record.url?scp=85131929282&partnerID=8YFLogxK
U2 - 10.1080/21645515.2022.2066424
DO - 10.1080/21645515.2022.2066424
M3 - Review Article
C2 - 35704772
AN - SCOPUS:85131929282
SN - 2164-5515
VL - 18
JO - Human Vaccines and Immunotherapeutics
JF - Human Vaccines and Immunotherapeutics
IS - 5
M1 - 2066424
ER -