Up-Regulation of the Vitamin D Pathway in Acute Myeloid Leukemia: A Novel Cause of Hypercalcemia

Joshua M. L. Casan, S. Ghoth, A. H. Wei, S. B. Ting, S. Morgan

Research output: Contribution to journalArticleOtherpeer-review


We report the first documented occurrence of hypercalcemia due to excessive production of calcitriol in acute myeloid leukemia (AML). The patient presented with severe hypercalcemia and renal failure accompanying a new diagnosis of AML. This extremely rare AML complication proved refractory to conventional hypercalcemia treatments but responded promptly to chemotherapy. Subsequent PCR studies performed on the leukemia blasts for vitamin D-related genes revealed dramatic up-regulation compared to healthy CD34+ cells and other primary AML cells. Recent data highlight a role for vitamin D in hematopoietic cell proliferation. Accordingly, this case may highlight another aspect of molecular heterogeneity in AML.
Original languageEnglish
Article number1141
JournalAnnals of Hematology & Oncology
Issue number3
Publication statusPublished - 2017

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