Up-Regulation of the Vitamin D Pathway in Acute Myeloid Leukemia: A Novel Cause of Hypercalcemia

Joshua M. L. Casan, S. Ghoth, A. H. Wei, S. B. Ting, S. Morgan

Research output: Contribution to journalArticleOtherpeer-review

Abstract

We report the first documented occurrence of hypercalcemia due to excessive production of calcitriol in acute myeloid leukemia (AML). The patient presented with severe hypercalcemia and renal failure accompanying a new diagnosis of AML. This extremely rare AML complication proved refractory to conventional hypercalcemia treatments but responded promptly to chemotherapy. Subsequent PCR studies performed on the leukemia blasts for vitamin D-related genes revealed dramatic up-regulation compared to healthy CD34+ cells and other primary AML cells. Recent data highlight a role for vitamin D in hematopoietic cell proliferation. Accordingly, this case may highlight another aspect of molecular heterogeneity in AML.
Original languageEnglish
Article number1141
JournalAnnals of Hematology and Oncology
Volume4
Issue number3
Publication statusPublished - 2017

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