We report the first documented occurrence of hypercalcemia due to excessive production of calcitriol in acute myeloid leukemia (AML). The patient presented with severe hypercalcemia and renal failure accompanying a new diagnosis of AML. This extremely rare AML complication proved refractory to conventional hypercalcemia treatments but responded promptly to chemotherapy. Subsequent PCR studies performed on the leukemia blasts for vitamin D-related genes revealed dramatic up-regulation compared to healthy CD34+ cells and other primary AML cells. Recent data highlight a role for vitamin D in hematopoietic cell proliferation. Accordingly, this case may highlight another aspect of molecular heterogeneity in AML.
|Journal||Annals of Hematology and Oncology|
|Publication status||Published - 2017|
Casan, J. M. L., Ghoth, S., Wei, A. H., Ting, S. B., & Morgan, S. (2017). Up-Regulation of the Vitamin D Pathway in Acute Myeloid Leukemia: A Novel Cause of Hypercalcemia. Annals of Hematology and Oncology, 4(3), .