@article{069db613051f42258032883440711877,
title = "Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL",
abstract = "Philadelphia-like (Ph-like) B-cell precursor acute lymphoblastic leaukemia (B-ALL) is a high-risk subtype of leukaemia [1]. It is characterized by a gene expression profile similar to Philadelphia chromosome positive (Ph+) ALL, but lacking the BCR::ABL1 rearrangement. Instead, Ph-like B-ALL represents a heterogeneous subtype driven by a diverse range of genetic aberrations and chromosomal rearrangements that converge on activated tyrosine kinase signalling [2, 3]. Integration of tyrosine kinase inhibitors into treatment regimens of Ph-like ALL patients has demonstrated early evidence of therapeutic efficacy, although results from larger clinical trials are pending [4].",
author = "Teresa Sadras and Jalud, {Fatimah B.} and Kosasih, {Hansen J.} and Horne, {Christopher R.} and Brown, {Lauren M.} and Sam El-Kamand and {de Bock}, {Charles E.} and Lachlan McAloney and Ng, {Ashley P.} and Davidson, {Nadia M.} and Ludlow, {Louise E.A.} and Alicia Oshlack and Cowley, {Mark J.} and Khaw, {Seong L.} and Murphy, {James M.} and Ekert, {Paul G.}",
note = "Funding Information: We gratefully acknowledge the Research Genomics Facility of the Victorian Clinical Genetics Service. Tumour samples and coded data were supplied by the Children{\textquoteright}s Cancer Centre Biobank at the Murdoch Children{\textquoteright}s Research Institute and The Royal Children{\textquoteright}s Hospital (mcri.edu.au/research/projects/childrens-cancer-centre-biobank). Establishment and running of the Children{\textquoteright}s Cancer Centre is made possible through generous support by Cancer In Kids @ RCH (www.cika.org.au ), The Royal Children{\textquoteright}s Hospital Foundation and the Murdoch Children{\textquoteright}s Research Institute and the Children{\textquoteright}s Cancer Centre Tissue Bank (Murdoch Children{\textquoteright}s Research Institute). This work is support by National Health and Medical Research Council Grants (1140626 to P.G.E.; 1172929 and 9000719 to JMM) and a SCOR Grant (7015-18) from the Lymphoma and Leukemia Society. We acknowledge the support of Perpetual Trustees and the Samuel Nissen Foundation. S.L.K. is supported by a fellowship from the Victorian Cancer Agency. This work was also supported by the Victorian Government{\textquoteright}s Operational Infrastructure Support Program. Funding Information: We gratefully acknowledge the Research Genomics Facility of the Victorian Clinical Genetics Service. Tumour samples and coded data were supplied by the Children{\textquoteright}s Cancer Centre Biobank at the Murdoch Children{\textquoteright}s Research Institute and The Royal Children{\textquoteright}s Hospital (mcri.edu.au/research/projects/childrens-cancer-centre-biobank). Establishment and running of the Children{\textquoteright}s Cancer Centre is made possible through generous support by Cancer In Kids @ RCH ( www.cika.org.au ), The Royal Children{\textquoteright}s Hospital Foundation and the Murdoch Children{\textquoteright}s Research Institute and the Children{\textquoteright}s Cancer Centre Tissue Bank (Murdoch Children{\textquoteright}s Research Institute). This work is support by National Health and Medical Research Council Grants (1140626 to P.G.E.; 1172929 and 9000719 to JMM) and a SCOR Grant (7015-18) from the Lymphoma and Leukemia Society. We acknowledge the support of Perpetual Trustees and the Samuel Nissen Foundation. S.L.K. is supported by a fellowship from the Victorian Cancer Agency. This work was also supported by the Victorian Government{\textquoteright}s Operational Infrastructure Support Program. ",
year = "2023",
month = apr,
doi = "10.1038/s41375-023-01843-x",
language = "English",
volume = "37",
pages = "905--909",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Nature Publishing Group",
number = "4",
}
