Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism

Anja Greule, Jeanette E. Stok, James J. De Voss, Max Cryle

Research output: Contribution to journalReview ArticleResearchpeer-review

60 Citations (Scopus)

Abstract

Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-containing monooxygenases that perform diverse catalytic roles in many species, including bacteria. The P450 superfamily is widely known for the hydroxylation of unactivated C-H bonds, but the diversity of reactions that P450s can perform vastly exceeds this undoubtedly impressive chemical transformation. Within bacteria, P450s play important roles in many biosynthetic and biodegradative processes that span a wide range of secondary metabolite pathways and present diverse chemical transformations. In this review, we aim to provide an overview of the range of chemical transformations that P450 enzymes can catalyse within bacterial secondary metabolism, with the intention to provide an important resource to aid in understanding of the potential roles of P450 enzymes within newly identified bacterial biosynthetic pathways.

Original languageEnglish
Pages (from-to)757-791
Number of pages35
JournalNatural Product Reports
Volume35
Issue number8
DOIs
Publication statusPublished - 1 Aug 2018

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