Unravelling the genetic links between Parkinson's disease and lung cancer

Yong Qi Leong, Rhun Yian Koh, Soi Moi Chye, Khuen Yen Ng

Research output: Contribution to journalReview ArticleResearchpeer-review


Increase evidence from epidemiological studies have shown an inverse association between Parkinson's disease (PD) and lung cancer. PD and lung cancer are both geriatric diseases, where these two diseases are sharing some common genetic determinants. Several PD-associated genes including alpha synuclein (SNCA), PTEN-induced kinase 1 (PINK1), parkin, parkinsonism associated deglycase (DJ-1), leucine-rich repeat kinase 2 (LRRK2), F-box protein 7 (FBXO7) and ubiquitin C-terminal hydrolase L1 (UCHL1) were reported to have altered expressions in lung cancer patients. This indicates that certain PD-associated genes might be important in conferring anticancer effects. This review aims to depict the physiological functions of these genes, and discuss the putative roles of these PD-associated genes in lung cancer. The understanding of the roles of these genes in the lung cancer progression might be important in the identification of new treatment targets for lung cancer. Gene therapy that aims to alter the expressions of these genes could be developed for future anticancer therapy. As a result, studying the roles of these genes in lung cancer may also help to understand their involvements as well as their roles in the pathogenesis of PD.

Original languageEnglish
Pages (from-to)551-567
Number of pages17
JournalBiological Chemistry
Issue number6
Publication statusPublished - 2023


  • lung cancer
  • non-small cell lung carcinoma
  • Parkinson's disease
  • PD-associated genes
  • small cell lung cancer
  • targeted therapy

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