Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models

S. Gerondakis, R. Grumont, R. Gugasyan, L. Wong, I. Isomura, W. Ho, A. Banerjee

Research output: Contribution to journalReview ArticleResearchpeer-review

226 Citations (Scopus)

Abstract

The nuclear factor-κB (NF-κB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-κB pathway, namely the IκB kinase subunits (IKKα, IKKβ and NEMO), the IκB proteins (IκBα, IκBβ, IκBε and Bcl-3) and the five NF-κB transcription factors (NF-κB1, NF-κB2, c-Rel, RelA and RelB), have been genetically manipulated using transgenic and knockout technology.

Original languageEnglish
Pages (from-to)6781-6799
Number of pages19
JournalOncogene
Volume25
Issue number51
DOIs
Publication statusPublished - 30 Oct 2006
Externally publishedYes

Keywords

  • IκB
  • IKK
  • Knockout mice
  • NF-κB
  • Transgenics

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