TY - JOUR
T1 - Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models
AU - Gerondakis, S.
AU - Grumont, R.
AU - Gugasyan, R.
AU - Wong, L.
AU - Isomura, I.
AU - Ho, W.
AU - Banerjee, A.
PY - 2006/10/30
Y1 - 2006/10/30
N2 - The nuclear factor-κB (NF-κB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-κB pathway, namely the IκB kinase subunits (IKKα, IKKβ and NEMO), the IκB proteins (IκBα, IκBβ, IκBε and Bcl-3) and the five NF-κB transcription factors (NF-κB1, NF-κB2, c-Rel, RelA and RelB), have been genetically manipulated using transgenic and knockout technology.
AB - The nuclear factor-κB (NF-κB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-κB pathway, namely the IκB kinase subunits (IKKα, IKKβ and NEMO), the IκB proteins (IκBα, IκBβ, IκBε and Bcl-3) and the five NF-κB transcription factors (NF-κB1, NF-κB2, c-Rel, RelA and RelB), have been genetically manipulated using transgenic and knockout technology.
KW - IκB
KW - IKK
KW - Knockout mice
KW - NF-κB
KW - Transgenics
UR - http://www.scopus.com/inward/record.url?scp=33750467991&partnerID=8YFLogxK
U2 - 10.1038/sj.onc.1209944
DO - 10.1038/sj.onc.1209944
M3 - Review Article
C2 - 17072328
AN - SCOPUS:33750467991
SN - 0950-9232
VL - 25
SP - 6781
EP - 6799
JO - Oncogene
JF - Oncogene
IS - 51
ER -
