Unraveling the links between the initiation of ventilation and brain injury in preterm infants

Samantha Kate Barton, Mary Tolcos, Suzanne Lee Miller, Charles Christopher Roehr, Georg Marcus Schmolzer, Peter G Davis, Timothy James Murugesan Moss, Domenic A LaRosa, Stuart Brian Hooper, Graeme Polglase

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The initiation of ventilation in the delivery room is one of the most important but least controlled interventions a preterm infant will face. Tidal volumes (V T) used in the neonatal intensive care unit are carefully measured and adjusted. However, the V Ts that an infant receives during resuscitation are usually unmonitored and highly variable. Inappropriate V Ts delivered to preterm infants during respiratory support substantially increase the risk of injury and inflammation to the lungs and brain. These may cause cerebral blood flow instability and initiate a cerebral inflammatory cascade. The two pathways increase the risk of brain injury and potential life-long adverse neurodevelopmental outcomes. The employment of new technologies, including respiratory function monitors, can improve and guide the optimal delivery of V Ts and reduce confounders, such as leak. Better respiratory support in the delivery room has the potential to improve both respiratory and neurological outcomes in this vulnerable population.
Original languageEnglish
Article number97
Number of pages9
JournalFrontiers in Pediatrics
Volume3
DOIs
Publication statusPublished - 2015

Cite this

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title = "Unraveling the links between the initiation of ventilation and brain injury in preterm infants",
abstract = "The initiation of ventilation in the delivery room is one of the most important but least controlled interventions a preterm infant will face. Tidal volumes (V T) used in the neonatal intensive care unit are carefully measured and adjusted. However, the V Ts that an infant receives during resuscitation are usually unmonitored and highly variable. Inappropriate V Ts delivered to preterm infants during respiratory support substantially increase the risk of injury and inflammation to the lungs and brain. These may cause cerebral blood flow instability and initiate a cerebral inflammatory cascade. The two pathways increase the risk of brain injury and potential life-long adverse neurodevelopmental outcomes. The employment of new technologies, including respiratory function monitors, can improve and guide the optimal delivery of V Ts and reduce confounders, such as leak. Better respiratory support in the delivery room has the potential to improve both respiratory and neurological outcomes in this vulnerable population.",
author = "Barton, {Samantha Kate} and Mary Tolcos and Miller, {Suzanne Lee} and Roehr, {Charles Christopher} and Schmolzer, {Georg Marcus} and Davis, {Peter G} and Moss, {Timothy James Murugesan} and LaRosa, {Domenic A} and Hooper, {Stuart Brian} and Graeme Polglase",
year = "2015",
doi = "10.3389/fped.2015.00097",
language = "English",
volume = "3",
journal = "Frontiers in Pediatrics",
issn = "2296-2360",
publisher = "Frontiers Media",

}

Unraveling the links between the initiation of ventilation and brain injury in preterm infants. / Barton, Samantha Kate; Tolcos, Mary; Miller, Suzanne Lee; Roehr, Charles Christopher; Schmolzer, Georg Marcus; Davis, Peter G; Moss, Timothy James Murugesan; LaRosa, Domenic A; Hooper, Stuart Brian; Polglase, Graeme.

In: Frontiers in Pediatrics, Vol. 3, 97, 2015.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Unraveling the links between the initiation of ventilation and brain injury in preterm infants

AU - Barton, Samantha Kate

AU - Tolcos, Mary

AU - Miller, Suzanne Lee

AU - Roehr, Charles Christopher

AU - Schmolzer, Georg Marcus

AU - Davis, Peter G

AU - Moss, Timothy James Murugesan

AU - LaRosa, Domenic A

AU - Hooper, Stuart Brian

AU - Polglase, Graeme

PY - 2015

Y1 - 2015

N2 - The initiation of ventilation in the delivery room is one of the most important but least controlled interventions a preterm infant will face. Tidal volumes (V T) used in the neonatal intensive care unit are carefully measured and adjusted. However, the V Ts that an infant receives during resuscitation are usually unmonitored and highly variable. Inappropriate V Ts delivered to preterm infants during respiratory support substantially increase the risk of injury and inflammation to the lungs and brain. These may cause cerebral blood flow instability and initiate a cerebral inflammatory cascade. The two pathways increase the risk of brain injury and potential life-long adverse neurodevelopmental outcomes. The employment of new technologies, including respiratory function monitors, can improve and guide the optimal delivery of V Ts and reduce confounders, such as leak. Better respiratory support in the delivery room has the potential to improve both respiratory and neurological outcomes in this vulnerable population.

AB - The initiation of ventilation in the delivery room is one of the most important but least controlled interventions a preterm infant will face. Tidal volumes (V T) used in the neonatal intensive care unit are carefully measured and adjusted. However, the V Ts that an infant receives during resuscitation are usually unmonitored and highly variable. Inappropriate V Ts delivered to preterm infants during respiratory support substantially increase the risk of injury and inflammation to the lungs and brain. These may cause cerebral blood flow instability and initiate a cerebral inflammatory cascade. The two pathways increase the risk of brain injury and potential life-long adverse neurodevelopmental outcomes. The employment of new technologies, including respiratory function monitors, can improve and guide the optimal delivery of V Ts and reduce confounders, such as leak. Better respiratory support in the delivery room has the potential to improve both respiratory and neurological outcomes in this vulnerable population.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639621/pdf/fped-03-00097.pdf

U2 - 10.3389/fped.2015.00097

DO - 10.3389/fped.2015.00097

M3 - Article

VL - 3

JO - Frontiers in Pediatrics

JF - Frontiers in Pediatrics

SN - 2296-2360

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ER -