Abstract
Changes in reward circuitry have been studied extensively in substance and behavioural addictions. However, comparatively little is known about the neurobiology underlying impulse control disorders (ICDs) in Parkinson’s disease, which show roughly similar risk factors and behavioural presentations to both stimulant and behavioural addictions. ICDs occur in a subset of susceptible patients with Parkinson’s disease (PD) following intake of dopamine replacement therapy (DRT). These behavioural disorders often have debilitating effects on a patient’s quality of life and increase caregiver burden. This comprehensive review examined findings of 40 neuroimaging studies of ICDs in PD to determine (a) whether there are putative neurobiological commonalities between traditional substance and behavioural addictions and DRT-induced ICD in PD and (b) opportunities for future studies to advance current neurobiological understanding of the phenomenon. Results revealed that strikingly similar (a) deficits in dopaminergic receptor expression, (b) connectivity changes in corticostriatal circuitry and (c) neural responses to cue exposure are observed in both ICDs in PD and addictive disorders. These findings point to the value of adopting a transdiagnostic approach when studying addicted populations and pave the way for demystifying this peculiar, often-devastating phenomenon in PD that has so far proven extremely difficult to treat and predict with any precision.
| Original language | English |
|---|---|
| Number of pages | 14 |
| Journal | Brain Imaging and Behavior |
| DOIs | |
| Publication status | Accepted/In press - 1 Feb 2019 |
Keywords
- Addiction
- Dopamine
- Impulse control disorders
- Neuroimaging
- Parkinson’s disease
Cite this
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Unmasking neurobiological commonalities between addictive disorders and impulse control disorders in Parkinson’s disease. / Ramdave, Swathi; Dawson, Andrew; Carter, Adrian; Dissanayaka, Nadeeka N.W.
In: Brain Imaging and Behavior, 01.02.2019.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Unmasking neurobiological commonalities between addictive disorders and impulse control disorders in Parkinson’s disease
AU - Ramdave, Swathi
AU - Dawson, Andrew
AU - Carter, Adrian
AU - Dissanayaka, Nadeeka N.W.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Changes in reward circuitry have been studied extensively in substance and behavioural addictions. However, comparatively little is known about the neurobiology underlying impulse control disorders (ICDs) in Parkinson’s disease, which show roughly similar risk factors and behavioural presentations to both stimulant and behavioural addictions. ICDs occur in a subset of susceptible patients with Parkinson’s disease (PD) following intake of dopamine replacement therapy (DRT). These behavioural disorders often have debilitating effects on a patient’s quality of life and increase caregiver burden. This comprehensive review examined findings of 40 neuroimaging studies of ICDs in PD to determine (a) whether there are putative neurobiological commonalities between traditional substance and behavioural addictions and DRT-induced ICD in PD and (b) opportunities for future studies to advance current neurobiological understanding of the phenomenon. Results revealed that strikingly similar (a) deficits in dopaminergic receptor expression, (b) connectivity changes in corticostriatal circuitry and (c) neural responses to cue exposure are observed in both ICDs in PD and addictive disorders. These findings point to the value of adopting a transdiagnostic approach when studying addicted populations and pave the way for demystifying this peculiar, often-devastating phenomenon in PD that has so far proven extremely difficult to treat and predict with any precision.
AB - Changes in reward circuitry have been studied extensively in substance and behavioural addictions. However, comparatively little is known about the neurobiology underlying impulse control disorders (ICDs) in Parkinson’s disease, which show roughly similar risk factors and behavioural presentations to both stimulant and behavioural addictions. ICDs occur in a subset of susceptible patients with Parkinson’s disease (PD) following intake of dopamine replacement therapy (DRT). These behavioural disorders often have debilitating effects on a patient’s quality of life and increase caregiver burden. This comprehensive review examined findings of 40 neuroimaging studies of ICDs in PD to determine (a) whether there are putative neurobiological commonalities between traditional substance and behavioural addictions and DRT-induced ICD in PD and (b) opportunities for future studies to advance current neurobiological understanding of the phenomenon. Results revealed that strikingly similar (a) deficits in dopaminergic receptor expression, (b) connectivity changes in corticostriatal circuitry and (c) neural responses to cue exposure are observed in both ICDs in PD and addictive disorders. These findings point to the value of adopting a transdiagnostic approach when studying addicted populations and pave the way for demystifying this peculiar, often-devastating phenomenon in PD that has so far proven extremely difficult to treat and predict with any precision.
KW - Addiction
KW - Dopamine
KW - Impulse control disorders
KW - Neuroimaging
KW - Parkinson’s disease
UR - http://www.scopus.com/inward/record.url?scp=85060974898&partnerID=8YFLogxK
U2 - 10.1007/s11682-019-00041-7
DO - 10.1007/s11682-019-00041-7
M3 - Review Article
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
SN - 1931-7557
ER -