Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms

Hywel D. Williams, Leigh Ford, Annabel Igonin, Zhenhua Shan, Paolo Botti, Michael M. Morgen, Guixian Hu, Colin W. Pouton, Peter J. Scammells, Christopher J.H. Porter, Hassan Benameur

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Lipid-based formulations (LBF) are widely used by industry and accepted by the regulatory authorities for oral drug delivery in the pharmaceutical and consumer healthcare market. Innovation in the LBF field is however needed in order to meet the demands of modern drugs, their more challenging problem statements and growing needs for achieving optimal pharmacokinetics (i.e., no food-effects, low variability) on approval. This review describes a new lipophilic salt / ionic liquid approach in combination with LBF, and how this salt strategy can be used to better tailor the properties of a drug to LBFs. The potential advantages of lipophilic salts are discussed in the context of dose escalation studies during toxicological evaluation, reducing the pill burden, increasing drug absorption of new drugs and in life-cycle management. Commentary on lipophilic salt synthesis, scale-up, LBF design and the regulatory aspects are also provided. These topics are discussed in the broad context of bringing the widely recognized advantages of LBFs to a broader spectrum of drugs.

Original languageEnglish
Number of pages16
JournalAdvanced Drug Delivery Reviews
DOIs
Publication statusAccepted/In press - 29 May 2019

Keywords

  • Absorption
  • Bioavailability
  • Ionic liquids
  • Lipid-based formulations
  • Lipophilic salts
  • SEDDS
  • Solubility

Cite this

Williams, H. D., Ford, L., Igonin, A., Shan, Z., Botti, P., Morgen, M. M., ... Benameur, H. (Accepted/In press). Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2019.05.008
Williams, Hywel D. ; Ford, Leigh ; Igonin, Annabel ; Shan, Zhenhua ; Botti, Paolo ; Morgen, Michael M. ; Hu, Guixian ; Pouton, Colin W. ; Scammells, Peter J. ; Porter, Christopher J.H. ; Benameur, Hassan. / Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms. In: Advanced Drug Delivery Reviews. 2019.
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Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms. / Williams, Hywel D.; Ford, Leigh; Igonin, Annabel; Shan, Zhenhua; Botti, Paolo; Morgen, Michael M.; Hu, Guixian; Pouton, Colin W.; Scammells, Peter J.; Porter, Christopher J.H.; Benameur, Hassan.

In: Advanced Drug Delivery Reviews, 29.05.2019.

Research output: Contribution to journalArticleResearchpeer-review

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