Uniform amorphous lactose microspheres formed in simultaneous convective and dehydration antisolvent precipitation under atmospheric conditions

Shahnaz Mansouri, Nan Fu, Meng Wai Woo, Xiao Dong Chen

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)


A simultaneous convection–dehydration and antisolvent precipitation approach has been shown to produce uniform microsized lactose particles from aqueous droplet at atmospheric pressure. Microparticles with high uniformity having diameters of between 1.0 and 2.4 μm have been obtained. The precipitation of the microparticles is driven by a unique self-assembly mechanism that cannot be fully elucidated by supersaturation alone. Further analysis suggests that structural changes in the solvent/antisolvent mixture, due to hydrophobic hydration, could play a role in the precipitation process observed.
Original languageEnglish
Pages (from-to)13772 - 13776
Number of pages5
Issue number39
Publication statusPublished - 2012

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