Uniform amorphous lactose microspheres formed in simultaneous convective and dehydration antisolvent precipitation under atmospheric conditions

Shahnaz Mansouri, Nan Fu, Meng Wai Woo, Xiao Dong Chen

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A simultaneous convection–dehydration and antisolvent precipitation approach has been shown to produce uniform microsized lactose particles from aqueous droplet at atmospheric pressure. Microparticles with high uniformity having diameters of between 1.0 and 2.4 μm have been obtained. The precipitation of the microparticles is driven by a unique self-assembly mechanism that cannot be fully elucidated by supersaturation alone. Further analysis suggests that structural changes in the solvent/antisolvent mixture, due to hydrophobic hydration, could play a role in the precipitation process observed.
Original languageEnglish
Pages (from-to)13772 - 13776
Number of pages5
JournalLangmuir: the ACS journal of surfaces and colloids
Volume28
Issue number39
DOIs
Publication statusPublished - 2012

Cite this

@article{5c6083228c2f49309f74f51b84b33498,
title = "Uniform amorphous lactose microspheres formed in simultaneous convective and dehydration antisolvent precipitation under atmospheric conditions",
abstract = "A simultaneous convection–dehydration and antisolvent precipitation approach has been shown to produce uniform microsized lactose particles from aqueous droplet at atmospheric pressure. Microparticles with high uniformity having diameters of between 1.0 and 2.4 μm have been obtained. The precipitation of the microparticles is driven by a unique self-assembly mechanism that cannot be fully elucidated by supersaturation alone. Further analysis suggests that structural changes in the solvent/antisolvent mixture, due to hydrophobic hydration, could play a role in the precipitation process observed.",
author = "Shahnaz Mansouri and Nan Fu and Woo, {Meng Wai} and Chen, {Xiao Dong}",
year = "2012",
doi = "10.1021/la302301h",
language = "English",
volume = "28",
pages = "13772 -- 13776",
journal = "Langmuir: the ACS journal of surfaces and colloids",
issn = "0743-7463",
publisher = "American Chemical Society (ACS)",
number = "39",

}

Uniform amorphous lactose microspheres formed in simultaneous convective and dehydration antisolvent precipitation under atmospheric conditions. / Mansouri, Shahnaz; Fu, Nan; Woo, Meng Wai; Chen, Xiao Dong.

In: Langmuir: the ACS journal of surfaces and colloids, Vol. 28, No. 39, 2012, p. 13772 - 13776.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Uniform amorphous lactose microspheres formed in simultaneous convective and dehydration antisolvent precipitation under atmospheric conditions

AU - Mansouri, Shahnaz

AU - Fu, Nan

AU - Woo, Meng Wai

AU - Chen, Xiao Dong

PY - 2012

Y1 - 2012

N2 - A simultaneous convection–dehydration and antisolvent precipitation approach has been shown to produce uniform microsized lactose particles from aqueous droplet at atmospheric pressure. Microparticles with high uniformity having diameters of between 1.0 and 2.4 μm have been obtained. The precipitation of the microparticles is driven by a unique self-assembly mechanism that cannot be fully elucidated by supersaturation alone. Further analysis suggests that structural changes in the solvent/antisolvent mixture, due to hydrophobic hydration, could play a role in the precipitation process observed.

AB - A simultaneous convection–dehydration and antisolvent precipitation approach has been shown to produce uniform microsized lactose particles from aqueous droplet at atmospheric pressure. Microparticles with high uniformity having diameters of between 1.0 and 2.4 μm have been obtained. The precipitation of the microparticles is driven by a unique self-assembly mechanism that cannot be fully elucidated by supersaturation alone. Further analysis suggests that structural changes in the solvent/antisolvent mixture, due to hydrophobic hydration, could play a role in the precipitation process observed.

UR - http://dx.doi.org/10.1021/1a30231h

U2 - 10.1021/la302301h

DO - 10.1021/la302301h

M3 - Article

VL - 28

SP - 13772

EP - 13776

JO - Langmuir: the ACS journal of surfaces and colloids

JF - Langmuir: the ACS journal of surfaces and colloids

SN - 0743-7463

IS - 39

ER -