Understanding the interfacial properties of nanostructured liquid crystalline materials for surface-specific delivery applications

Yao Da Charlie Dong, Ian Clair Larson, Timothy Barnes, Clive Allan Prestidge, Stephanie Allen, Xinyong Chen, Clive J Roberts, Benjamin James Boyd

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)


Nonlamellar liquid crystalline dispersions such as cubosomes and hexosomes have great potential as novel surface-targeted active delivery systems. In this study, the influence of internal nanostructure, chemical composition, and the presence of Pluronic F127 as a stabilizer, on the surface and interfacial properties of different liquid crystalline particles and surfaces, was investigated. The interfacial properties of the bulk liquid crystalline systems with coexisting excess water were dependent on the internal liquid crystalline nanostructure. In particular, the surfaces of the inverse cubic systems were more hydrophilic than that of the inverse hexagonal phase. The interaction between F127 and the bulk liquid crystalline systems depended on the internal liquid crystalline structure and chemical composition. For example, F127 adsorbed to the surface of the bulk phytantriol cubic phase, while for monoolein cubic phase, F127 was integrated into the liquid crystalline structure. Last, the interfacial adsorption behavior of the dispersed liquid crystalline particles also depended on both the internal nanostructure and the chemical composition, despite the dispersions all being stabilized using F127. The findings highlight the need to understand the specific surface characteristics and the nature of the interaction with colloidal stabilizer for understanding and optimizing the behavior of nonlamellar liquid crystalline systems in surface delivery applications.
Original languageEnglish
Pages (from-to)13485 - 13495
Number of pages11
Issue number37
Publication statusPublished - 2012

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