Understanding principles of integration and segregation using whole-brain computational connectomics: Implications for neuropsychiatric disorders

Louis David Lord, Angus B.A. Stevner, Gustavo Deco, Morten L. Kringelbach

Research output: Contribution to journalReview ArticleResearchpeer-review

50 Citations (Scopus)


To survive in an ever-changing environment, the brain must seamlessly integrate a rich stream of incoming information into coherent internal representations that can then be used to efficiently plan for action. The brain must, however, balance its ability to integrate information from various sources with a complementary capacity to segregate information into modules which perform specialized computations in local circuits. Importantly, evidence suggests that imbalances in the brain's ability to bind together and/or segregate information over both space and time is a common feature of several neuropsychiatric disorders. Most studies have, however, until recently strictly attempted to characterize the principles of integration and segregation in static (i.e. time-invariant) representations of human brain networks, hence disregarding the complex spatio-temporal nature of these processes. In the present Review, we describe how the emerging discipline of whole-brain computational connectomics may be used to study the causal mechanisms of the integration and segregation of information on behaviourally relevant timescales. We emphasize how novel methods from network science and whole-brain computational modelling can expand beyond traditional neuroimaging paradigms and help to uncover the neurobiological determinants of the abnormal integration and segregation of information in neuropsychiatric disorders. This article is part of the themed issue 'Mathematical methods in medicine: neuroscience, cardiology and pathology'.

Original languageEnglish
Article number20160283
Number of pages21
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Issue number2096
Publication statusPublished - 28 Jun 2017


  • Brain connectivity
  • Computational modelling
  • Integration and segregation
  • Network analysis
  • Neuropsychiatric disorders

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