Understanding mucosal responsiveness: Lessons from enteric bacterial pathogens

Cameron P. Simmons, Simon Clare, Gordon Dougan

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)


Mucosal immune responses must discriminate between commensal flora within the lumen and potential pathogens. These responses are highly adapted to induce protection without excessive inflammation. The balances that regulate mucosal immune and inflammatory responses have to be understood if effective mucosal immunity is to be induced through local immunization. This review will summarize some of the lessons learnt from studies of antigens derived from enteric bacterial pathogens and discuss how the gastrointestinal epithelia can 'fight back' when it encounters pathogens.

Original languageEnglish
Pages (from-to)201-209
Number of pages9
JournalSeminars in Immunology
Issue number3
Publication statusPublished - 1 Jan 2001
Externally publishedYes


  • Bacteria
  • Epithelia
  • Gastrointestinal
  • Pathogen

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