Understanding improved dissolution of indomethacin through the use of cohesive poorly water-soluble aluminium hydroxide: Effects of concentration and particle size distribution

Tracy Tay, Ayman Allahham, David Morton, Peter Stewart

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

The objective of this study was to explore the effects of concentration and particle size distribution of an added poorly water-soluble inorganic salt, aluminium hydroxide, on the dissolution of a poorly water-soluble drug, indomethacin (IMC), from lactose interactive mixtures. Dissolution was studied using the United States Pharmacopeia paddle method in buffer pH 5.0 and the data most aptly fitted a bi-exponential dissolution model which represented dissolution occurring from dispersed and agglomerated particles. The dispersion of IMC mixtures was measured in dissolution media under non-sink conditions by laser diffraction
Original languageEnglish
Pages (from-to)4269 - 4280
Number of pages12
JournalJournal of Pharmaceutical Sciences
Volume100
Issue number10
DOIs
Publication statusPublished - 2011

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