TY - JOUR
T1 - Understanding effects of process parameters and forced feeding on die filling
AU - Goh, Hui Ping
AU - Heng, Paul Wan Sia
AU - Liew, Celine Valeria
N1 - Funding Information:
The authors would like to acknowledge the financial support from GEA-NUS PPRL fund ( N-148-000-008-001 ). Goh Hui Ping is a recipient of the National University of Singapore Graduate Research Scholarship. The authors also wish to acknowledge the assistance of the Workshop at Department of Physics, NUS, especially the manager Mr. Goh Eng Kee, in the fabrication of the die fill device.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/9/15
Y1 - 2018/9/15
N2 - Die filling is a critical step during pharmaceutical tablet production and is still not well understood due to the rather complex interplay between particle attributes, die orifice diameter and fill energetics. While shoe-die filling models have been used to simulate die filling conditions, they typically lack the sophistication of the actual production-scale, feeder-based die filling conditions. The relationship between tableting process parameters and filling into die orifices of different diameters by powders of different flowabilities requires critical examination and understanding. In this study, a special die filling contraption was designed and custom-made to simulate the effects of gravity, suction and feeder paddle assistance as present in modern rotary tablet presses. Die fill performance was studied using powders with different flow properties. Suction impact was greatest on die fill, in particular, for small orifice diameters and less permeable powders. Effect of paddle velocity on die fill was greater for compressible powders and larger orifice diameters. In comparison to suction and paddle velocity, forced feeding did not significantly affect die fill performance. Relationship between process parameters and die fill performance was found to be highly dependent on the material and orifice diameter.
AB - Die filling is a critical step during pharmaceutical tablet production and is still not well understood due to the rather complex interplay between particle attributes, die orifice diameter and fill energetics. While shoe-die filling models have been used to simulate die filling conditions, they typically lack the sophistication of the actual production-scale, feeder-based die filling conditions. The relationship between tableting process parameters and filling into die orifices of different diameters by powders of different flowabilities requires critical examination and understanding. In this study, a special die filling contraption was designed and custom-made to simulate the effects of gravity, suction and feeder paddle assistance as present in modern rotary tablet presses. Die fill performance was studied using powders with different flow properties. Suction impact was greatest on die fill, in particular, for small orifice diameters and less permeable powders. Effect of paddle velocity on die fill was greater for compressible powders and larger orifice diameters. In comparison to suction and paddle velocity, forced feeding did not significantly affect die fill performance. Relationship between process parameters and die fill performance was found to be highly dependent on the material and orifice diameter.
KW - Die fill
KW - Forced feeding
KW - Orifice diameter
KW - Paddle velocity
KW - Tableting process
UR - http://www.scopus.com/inward/record.url?scp=85049339586&partnerID=8YFLogxK
U2 - 10.1016/j.ejps.2018.06.026
DO - 10.1016/j.ejps.2018.06.026
M3 - Article
C2 - 29959985
AN - SCOPUS:85049339586
SN - 0928-0987
VL - 122
SP - 105
EP - 115
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
ER -