Understanding crossmatch testing in organ transplantation: A case-based guide for the general nephrologist

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Abstract

Crossmatching of potential renal donors against potential renal transplant recipients has been performed for over 40 years and is a mandatory component of the transplant work-up process. However, gone are the days when all that was available was the T-cell complement-dependent cytotoxicity crossmatch. There are now many more options available for determining the likelihood of donor-specific antibody-mediated responses including flow crossmatching and the virtual crossmatch. In addition, assays to determine the extent of sensitization of cell-mediated responses are being examined. This article builds an understanding of modern day crossmatch interpretation using a case-based approach in order to provide a framework for the general nephrologist to determine the likely immune consequences of a particular donor-recipient pairing.
Original languageEnglish
Pages (from-to)125 - 133
Number of pages9
JournalNephrology
Volume16
Issue number2
DOIs
Publication statusPublished - 2011

Cite this

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abstract = "Crossmatching of potential renal donors against potential renal transplant recipients has been performed for over 40 years and is a mandatory component of the transplant work-up process. However, gone are the days when all that was available was the T-cell complement-dependent cytotoxicity crossmatch. There are now many more options available for determining the likelihood of donor-specific antibody-mediated responses including flow crossmatching and the virtual crossmatch. In addition, assays to determine the extent of sensitization of cell-mediated responses are being examined. This article builds an understanding of modern day crossmatch interpretation using a case-based approach in order to provide a framework for the general nephrologist to determine the likely immune consequences of a particular donor-recipient pairing.",
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Understanding crossmatch testing in organ transplantation: A case-based guide for the general nephrologist. / Mulley, William; Kanellis, John.

In: Nephrology, Vol. 16, No. 2, 2011, p. 125 - 133.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Understanding crossmatch testing in organ transplantation: A case-based guide for the general nephrologist

AU - Mulley, William

AU - Kanellis, John

PY - 2011

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AB - Crossmatching of potential renal donors against potential renal transplant recipients has been performed for over 40 years and is a mandatory component of the transplant work-up process. However, gone are the days when all that was available was the T-cell complement-dependent cytotoxicity crossmatch. There are now many more options available for determining the likelihood of donor-specific antibody-mediated responses including flow crossmatching and the virtual crossmatch. In addition, assays to determine the extent of sensitization of cell-mediated responses are being examined. This article builds an understanding of modern day crossmatch interpretation using a case-based approach in order to provide a framework for the general nephrologist to determine the likely immune consequences of a particular donor-recipient pairing.

UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1797.2010.01414.x/pdf

U2 - 10.1111/j.1440-1797.2010.01414.x

DO - 10.1111/j.1440-1797.2010.01414.x

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EP - 133

JO - Nephrology

JF - Nephrology

SN - 1320-5358

IS - 2

ER -