Understanding Cell Interactions Using Modular Nanoparticle Libraries

Georgina K. Such, Angus P.R. Johnston

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Nanoparticle delivery systems have significant potential to facilitate the delivery of novel therapeutics, such as proteins, DNA or small molecules. However, there are multiple biological barriers that need to be overcome to deliver the cargo in an active form. These challenges include evading clearance by the reticuloendothelial system, minimising adverse immune responses, targeting specific cells and tissues, and trafficking into the right compartment of the cell. In this account, we will discuss how nanoparticle structure can be tuned to optimise biological interactions and thus improve the ability of nanoparticles to overcome these barriers. The focus of this article will be on controlling cell targeting and trafficking within a cell, e.g. endosomal escape.

Original languageEnglish
Pages (from-to)595-599
Number of pages5
JournalAustralian Journal of Chemistry
Volume72
Issue number8
DOIs
Publication statusPublished - 14 Aug 2019

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