Understanding amylin Receptors

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Abstract

Amylin is a 37 amino acid peptide that is co-secreted with insulin from pancreatic β-cells following nutrient ingestion, acting to inhibit gastric emptying, feeding and insulin-stimulated glycogen synthesis. Amylin is a member of the calcitonin (CT) family of peptides, which include CT, CT gene-related peptides (CGRP) and adrenomedullin (AM). The receptors for these peptides comprise the CT receptor (CTR) and the CTR-like receptor (CLR) that may be complexed with one of three receptor activity modifying proteins (RAMPs). Amylin receptors are formed when the CTR is in complex with RAMP1, RAMP2 or RAMP3, forming AMY1, AMY2 and AMY3 receptors, respectively. Each of these receptors, while binding amylin with similar affinity, has a distinct agonist and antagonist pharmacology. Analysis of RAMP chimeras and deletion constructs has provided insight into domains of RAMPs that contribute to ligand and signaling specificity. The N-terminal domain is the principle domain involved in alteration of ligand binding specificity, while the C-terminal domain contributes to the peptide signaling profile of the receptor complexes and could be directly involved in the interaction with G proteins.

Original languageEnglish
Title of host publicationThe Calcitonin Gene-related Peptide Family: Form, Function and Future Perspectives
PublisherSpringer
Pages41-57
Number of pages17
ISBN (Electronic)9789048129096
ISBN (Print)9789048129089
DOIs
Publication statusPublished - 2010

Keywords

  • Amylin receptors
  • Calcitonin receptors
  • G protein
  • Pharmacology
  • Receptor activity modifying proteins
  • Regulation
  • Signaling
  • Structure-function

Cite this

Just, R., Simms, J., Furness, S. G. B., Christopoulos, A., & Sexton, P. M. (2010). Understanding amylin Receptors. In The Calcitonin Gene-related Peptide Family: Form, Function and Future Perspectives (pp. 41-57). Springer. https://doi.org/10.1007/978-90-481-2909-6_3