Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women

Itamar Levinger, David Scott, Geoffrey C Nicholson, Amanda Stuart, Gustavo Duque, Thomas McCorquodale, Markus Herrmann, Peter Robert Ebeling, Kerrie Margaret Sanders

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43 Citations (Scopus)

Abstract

We investigated the association between undercarboxylated osteocalcin (ucOC) and lower-limb muscle strength in women over the age of 70years. The study also aims to confirm the association between bone turnover markers and heel ultrasound measures. A post-hoc analysis using data collected as part of a randomized placebo-controlled trial of vitamin D supplementation. An immunoassay was used to quantify total OC (tOC), with hydroxyapatite pre-treatment for ucOC. We determined associations of absolute and relative (ucOC/tOC; ucOC ) measures of ucOC with lower-limb muscle strength, heel ultrasound measures of speed of sound (SOS) and broadband ultrasound attenuation (BUA), bone turnover markers (BTMs; P1NP and CTx) and the acute phase protein alpha-1-antichymotrypsin (a-ACT). ucOC , but not absolute ucOC concentration, was positively associated with hip flexor, hip abductor and quadriceps muscle strength (all p
Original languageEnglish
Pages (from-to)8 - 12
Number of pages5
JournalBone
Volume64
DOIs
Publication statusPublished - 2014

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