Uncovering the metabolic strategies of the dormant microbial majority: Towards integrative approaches

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

A grand challenge in microbiology is to understand how the dormant majority lives. In natural environments, most microorganisms are not growing and instead exist in a spectrum of dormant states. Despite this, most research on microbial metabolism continues to be growth-centric, and many overlook the fact that dormant cells require energy for maintenance. In this perspective, we discuss our research program to uncover the metabolic strategies that support microbial survival. We present two major principles underlying these studies. The first is the recent realization that microbial survival depends on previously unrecognized metabolic flexibility. The second is that new discoveries in this area depend on more sophisticated integration of approaches at the molecular, cellular, and ecosystem levels. These principles are illustrated with examples from the literature, including our own work demonstrating that bacteria can live on air, and areas for future methodological and theoretical development are highlighted.

Original languageEnglish
Article numbere00107-19
Number of pages5
JournalmSystems
Volume4
Issue number3
DOIs
Publication statusPublished - 1 May 2019

Keywords

  • Hydrogen
  • Metabolism
  • Mycobacteria
  • Persistence
  • Soil microbiology
  • Trace gases

Cite this

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title = "Uncovering the metabolic strategies of the dormant microbial majority: Towards integrative approaches",
abstract = "A grand challenge in microbiology is to understand how the dormant majority lives. In natural environments, most microorganisms are not growing and instead exist in a spectrum of dormant states. Despite this, most research on microbial metabolism continues to be growth-centric, and many overlook the fact that dormant cells require energy for maintenance. In this perspective, we discuss our research program to uncover the metabolic strategies that support microbial survival. We present two major principles underlying these studies. The first is the recent realization that microbial survival depends on previously unrecognized metabolic flexibility. The second is that new discoveries in this area depend on more sophisticated integration of approaches at the molecular, cellular, and ecosystem levels. These principles are illustrated with examples from the literature, including our own work demonstrating that bacteria can live on air, and areas for future methodological and theoretical development are highlighted.",
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Uncovering the metabolic strategies of the dormant microbial majority : Towards integrative approaches. / Greening, Christopher Andrew; Grinter, Rhys William; Chiri, Eleonora.

In: mSystems, Vol. 4, No. 3, e00107-19, 01.05.2019.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Uncovering the metabolic strategies of the dormant microbial majority

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AU - Greening, Christopher Andrew

AU - Grinter, Rhys William

AU - Chiri, Eleonora

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AB - A grand challenge in microbiology is to understand how the dormant majority lives. In natural environments, most microorganisms are not growing and instead exist in a spectrum of dormant states. Despite this, most research on microbial metabolism continues to be growth-centric, and many overlook the fact that dormant cells require energy for maintenance. In this perspective, we discuss our research program to uncover the metabolic strategies that support microbial survival. We present two major principles underlying these studies. The first is the recent realization that microbial survival depends on previously unrecognized metabolic flexibility. The second is that new discoveries in this area depend on more sophisticated integration of approaches at the molecular, cellular, and ecosystem levels. These principles are illustrated with examples from the literature, including our own work demonstrating that bacteria can live on air, and areas for future methodological and theoretical development are highlighted.

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KW - Metabolism

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KW - Persistence

KW - Soil microbiology

KW - Trace gases

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