Uncovering protein–protein interactions through a team-based undergraduate biochemistry course

David L. Cookmeyer, Emily S. Winesett, Bashkim Kokona, Adam R. Huff, Sabina Aliev, Noah B. Bloch, Joshua A. Bulos, Irene L. Evans, Christian R. Fagre, Kerilyn N. Godbe, Maryna Khromava, Daniel M. Konstantinovsky, Alexander E. Lafrance, Alexandra J. Lamacki, Robert C. Parry, Jeanne M. Quinn, Alana M. Thurston, Kathleen J.S. Tsai, Aurelio Mollo, Max J. Cryle & 2 others Robert Fairman, Louise K. Charkoudian

Research output: Contribution to journalArticleResearchpeer-review

Abstract

How can we provide fertile ground for students to simultaneously explore a breadth of foundational knowledge, develop cross-disciplinary problem-solving skills, gain resiliency, and learn to work as a member of a team? One way is to integrate original research in the context of an undergraduate biochemistry course. In this Community Page, we discuss the development and execution of an interdisciplinary and cross-departmental undergraduate biochemistry laboratory course. We present a template for how a similar course can be replicated at other institutions and provide pedagogical and research results from a sample module in which we challenged our students to study the binding interface between 2 important biosynthetic proteins. Finally, we address the community and invite others to join us in making a larger impact on undergraduate education and the field of biochemistry by coordinating efforts to integrate research and teaching across campuses.

Original languageEnglish
Article numbere2003145
Number of pages13
JournalPLoS Biology
Volume15
Issue number11
DOIs
Publication statusPublished - 1 Nov 2017

Cite this

Cookmeyer, D. L., Winesett, E. S., Kokona, B., Huff, A. R., Aliev, S., Bloch, N. B., ... Charkoudian, L. K. (2017). Uncovering protein–protein interactions through a team-based undergraduate biochemistry course. PLoS Biology, 15(11), [e2003145]. https://doi.org/10.1371/journal.pbio.2003145
Cookmeyer, David L. ; Winesett, Emily S. ; Kokona, Bashkim ; Huff, Adam R. ; Aliev, Sabina ; Bloch, Noah B. ; Bulos, Joshua A. ; Evans, Irene L. ; Fagre, Christian R. ; Godbe, Kerilyn N. ; Khromava, Maryna ; Konstantinovsky, Daniel M. ; Lafrance, Alexander E. ; Lamacki, Alexandra J. ; Parry, Robert C. ; Quinn, Jeanne M. ; Thurston, Alana M. ; Tsai, Kathleen J.S. ; Mollo, Aurelio ; Cryle, Max J. ; Fairman, Robert ; Charkoudian, Louise K. / Uncovering protein–protein interactions through a team-based undergraduate biochemistry course. In: PLoS Biology. 2017 ; Vol. 15, No. 11.
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abstract = "How can we provide fertile ground for students to simultaneously explore a breadth of foundational knowledge, develop cross-disciplinary problem-solving skills, gain resiliency, and learn to work as a member of a team? One way is to integrate original research in the context of an undergraduate biochemistry course. In this Community Page, we discuss the development and execution of an interdisciplinary and cross-departmental undergraduate biochemistry laboratory course. We present a template for how a similar course can be replicated at other institutions and provide pedagogical and research results from a sample module in which we challenged our students to study the binding interface between 2 important biosynthetic proteins. Finally, we address the community and invite others to join us in making a larger impact on undergraduate education and the field of biochemistry by coordinating efforts to integrate research and teaching across campuses.",
author = "Cookmeyer, {David L.} and Winesett, {Emily S.} and Bashkim Kokona and Huff, {Adam R.} and Sabina Aliev and Bloch, {Noah B.} and Bulos, {Joshua A.} and Evans, {Irene L.} and Fagre, {Christian R.} and Godbe, {Kerilyn N.} and Maryna Khromava and Konstantinovsky, {Daniel M.} and Lafrance, {Alexander E.} and Lamacki, {Alexandra J.} and Parry, {Robert C.} and Quinn, {Jeanne M.} and Thurston, {Alana M.} and Tsai, {Kathleen J.S.} and Aurelio Mollo and Cryle, {Max J.} and Robert Fairman and Charkoudian, {Louise K.}",
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Cookmeyer, DL, Winesett, ES, Kokona, B, Huff, AR, Aliev, S, Bloch, NB, Bulos, JA, Evans, IL, Fagre, CR, Godbe, KN, Khromava, M, Konstantinovsky, DM, Lafrance, AE, Lamacki, AJ, Parry, RC, Quinn, JM, Thurston, AM, Tsai, KJS, Mollo, A, Cryle, MJ, Fairman, R & Charkoudian, LK 2017, 'Uncovering protein–protein interactions through a team-based undergraduate biochemistry course' PLoS Biology, vol. 15, no. 11, e2003145. https://doi.org/10.1371/journal.pbio.2003145

Uncovering protein–protein interactions through a team-based undergraduate biochemistry course. / Cookmeyer, David L.; Winesett, Emily S.; Kokona, Bashkim; Huff, Adam R.; Aliev, Sabina; Bloch, Noah B.; Bulos, Joshua A.; Evans, Irene L.; Fagre, Christian R.; Godbe, Kerilyn N.; Khromava, Maryna; Konstantinovsky, Daniel M.; Lafrance, Alexander E.; Lamacki, Alexandra J.; Parry, Robert C.; Quinn, Jeanne M.; Thurston, Alana M.; Tsai, Kathleen J.S.; Mollo, Aurelio; Cryle, Max J.; Fairman, Robert; Charkoudian, Louise K.

In: PLoS Biology, Vol. 15, No. 11, e2003145, 01.11.2017.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Uncovering protein–protein interactions through a team-based undergraduate biochemistry course

AU - Cookmeyer, David L.

AU - Winesett, Emily S.

AU - Kokona, Bashkim

AU - Huff, Adam R.

AU - Aliev, Sabina

AU - Bloch, Noah B.

AU - Bulos, Joshua A.

AU - Evans, Irene L.

AU - Fagre, Christian R.

AU - Godbe, Kerilyn N.

AU - Khromava, Maryna

AU - Konstantinovsky, Daniel M.

AU - Lafrance, Alexander E.

AU - Lamacki, Alexandra J.

AU - Parry, Robert C.

AU - Quinn, Jeanne M.

AU - Thurston, Alana M.

AU - Tsai, Kathleen J.S.

AU - Mollo, Aurelio

AU - Cryle, Max J.

AU - Fairman, Robert

AU - Charkoudian, Louise K.

PY - 2017/11/1

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N2 - How can we provide fertile ground for students to simultaneously explore a breadth of foundational knowledge, develop cross-disciplinary problem-solving skills, gain resiliency, and learn to work as a member of a team? One way is to integrate original research in the context of an undergraduate biochemistry course. In this Community Page, we discuss the development and execution of an interdisciplinary and cross-departmental undergraduate biochemistry laboratory course. We present a template for how a similar course can be replicated at other institutions and provide pedagogical and research results from a sample module in which we challenged our students to study the binding interface between 2 important biosynthetic proteins. Finally, we address the community and invite others to join us in making a larger impact on undergraduate education and the field of biochemistry by coordinating efforts to integrate research and teaching across campuses.

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M3 - Article

VL - 15

JO - PLoS Biology

JF - PLoS Biology

SN - 1544-9173

IS - 11

M1 - e2003145

ER -

Cookmeyer DL, Winesett ES, Kokona B, Huff AR, Aliev S, Bloch NB et al. Uncovering protein–protein interactions through a team-based undergraduate biochemistry course. PLoS Biology. 2017 Nov 1;15(11). e2003145. https://doi.org/10.1371/journal.pbio.2003145