TY - JOUR
T1 - Unbalanced translocations of 20q in AML and MDS often involve interstitial rather than terminal deletions of 20q
AU - MacKinnon, Ruth N.
AU - Duivenvoorden, Hendrika M.
AU - Campbell, Lynda J.
PY - 2011/3/1
Y1 - 2011/3/1
N2 - Dicentric chromosomes can occur in myelodysplastic syndromes and acute myeloid leukemia. As these unbalanced rearrangements often combine two recurrent deletions, they could be an efficient mechanism for the loss of two tumor suppressor genes in a single step. We report here that dicentric chromosomes involving chromosome 20 with loss of the 20q12 putative tumor suppressor gene are often the result of more complex rearrangements, with the 20q12 region being lost by an interstitial deletion independent of the site of translocation. We found interstitial deletions of 20q in two thirds of the two-way translocations tested. This points to a more complex mechanism of translocation involving at least three breakpoints and two separate events, and raises questions about the order of these events and the significance of these abnormalities.
AB - Dicentric chromosomes can occur in myelodysplastic syndromes and acute myeloid leukemia. As these unbalanced rearrangements often combine two recurrent deletions, they could be an efficient mechanism for the loss of two tumor suppressor genes in a single step. We report here that dicentric chromosomes involving chromosome 20 with loss of the 20q12 putative tumor suppressor gene are often the result of more complex rearrangements, with the 20q12 region being lost by an interstitial deletion independent of the site of translocation. We found interstitial deletions of 20q in two thirds of the two-way translocations tested. This points to a more complex mechanism of translocation involving at least three breakpoints and two separate events, and raises questions about the order of these events and the significance of these abnormalities.
KW - Acute myeloid leukemia
KW - Chromosome 20 deletion
KW - Dicentric
KW - Interstitial deletion
KW - Myelodysplastic syndromes
UR - http://www.scopus.com/inward/record.url?scp=79960681711&partnerID=8YFLogxK
U2 - 10.1016/j.cancergen.2010.12.001
DO - 10.1016/j.cancergen.2010.12.001
M3 - Article
C2 - 21504715
AN - SCOPUS:79960681711
VL - 204
SP - 153
EP - 161
JO - Cancer Genetics
JF - Cancer Genetics
SN - 2210-7762
IS - 3
ER -