Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans

Amanda K.E. Hornsby, Luke Buntwal, Maria Carla Carisi, Vanessa V. Santos, Fionnuala Johnston, Luke D. Roberts, Martina Sassi, Mathieu Mequinion, Romana Stark, Alex Reichenbach, Sarah H. Lockie, Mario Siervo, Owain Howell, Alwena H. Morgan, Timothy Wells, Zane B. Andrews, David J. Burn, Jeffrey S. Davies

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)


The gut-hormone acyl-ghrelin (AG) is known to promote adult hippocampal neurogenesis. Hornsby et al. combine in vitro and in vivo rodent models, alongside analysis of human plasma, to show that unacylated-ghrelin (UAG) impairs neurogenesis and that the circulating AG:UAG ratio is reduced in Parkinson's dementia.

Original languageEnglish
Article number100120
Pages (from-to)1-e9
Number of pages23
JournalCell Reports Medicine
Issue number7
Publication statusPublished - 20 Oct 2020


  • acyl-ghrelin
  • adult hippocampal neurogenesis
  • AG:UAG
  • BDNF
  • biomarker
  • ghrelin
  • GOAT
  • memory
  • Parkinson disease dementia
  • unacylated-ghrelin

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