Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans

Amanda K.E. Hornsby; Luke Buntwal; Maria Carla Carisi; Vanessa V. Santos; Fionnuala Johnston; Luke D. Roberts; Martina Sassi; Mathieu Mequinion; Romana Stark; Alex Reichenbach; Sarah H. Lockie; Mario Siervo; Owain Howell; Alwena H. Morgan; Timothy Wells; Zane B. Andrews; David J. Burn; Jeffrey S. Davies

doi:10.1016/j.xcrm.2020.100120

Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans

Amanda K.E. Hornsby, Luke Buntwal, Maria Carla Carisi, Vanessa V. Santos, Fionnuala Johnston, Luke D. Roberts, Martina Sassi, Mathieu Mequinion, Romana Stark, Alex Reichenbach, Sarah H. Lockie, Mario Siervo, Owain Howell, Alwena H. Morgan, Timothy Wells, Zane B. Andrews, David J. Burn, Jeffrey S. Davies

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

The gut-hormone acyl-ghrelin (AG) is known to promote adult hippocampal neurogenesis. Hornsby et al. combine in vitro and in vivo rodent models, alongside analysis of human plasma, to show that unacylated-ghrelin (UAG) impairs neurogenesis and that the circulating AG:UAG ratio is reduced in Parkinson's dementia.

Original language	English
Article number	100120
Pages (from-to)	1-e9
Number of pages	23
Journal	Cell Reports Medicine
Volume	1
Issue number	7
DOIs	https://doi.org/10.1016/j.xcrm.2020.100120
Publication status	Published - 20 Oct 2020

Keywords

acyl-ghrelin
adult hippocampal neurogenesis
AG:UAG
BDNF
biomarker
ghrelin
GOAT
memory
Parkinson disease dementia
unacylated-ghrelin

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10.1016/j.xcrm.2020.100120Licence: CC BY

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Hornsby, A. K. E., Buntwal, L., Carisi, M. C., Santos, V. V., Johnston, F., Roberts, L. D., Sassi, M., Mequinion, M., Stark, R., Reichenbach, A., Lockie, S. H., Siervo, M., Howell, O., Morgan, A. H., Wells, T., Andrews, Z. B., Burn, D. J., & Davies, J. S. (2020). Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans. Cell Reports Medicine, 1(7), 1-e9. Article 100120. https://doi.org/10.1016/j.xcrm.2020.100120

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title = "Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans",

abstract = "The gut-hormone acyl-ghrelin (AG) is known to promote adult hippocampal neurogenesis. Hornsby et al. combine in vitro and in vivo rodent models, alongside analysis of human plasma, to show that unacylated-ghrelin (UAG) impairs neurogenesis and that the circulating AG:UAG ratio is reduced in Parkinson's dementia.",

keywords = "acyl-ghrelin, adult hippocampal neurogenesis, AG:UAG, BDNF, biomarker, ghrelin, GOAT, memory, Parkinson disease dementia, unacylated-ghrelin",

author = "Hornsby, {Amanda K.E.} and Luke Buntwal and Carisi, {Maria Carla} and Santos, {Vanessa V.} and Fionnuala Johnston and Roberts, {Luke D.} and Martina Sassi and Mathieu Mequinion and Romana Stark and Alex Reichenbach and Lockie, {Sarah H.} and Mario Siervo and Owain Howell and Morgan, {Alwena H.} and Timothy Wells and Andrews, {Zane B.} and Burn, {David J.} and Davies, {Jeffrey S.}",

year = "2020",

month = oct,

day = "20",

doi = "10.1016/j.xcrm.2020.100120",

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Hornsby, AKE, Buntwal, L, Carisi, MC, Santos, VV, Johnston, F, Roberts, LD, Sassi, M, Mequinion, M, Stark, R , Reichenbach, A , Lockie, SH, Siervo, M, Howell, O, Morgan, AH, Wells, T, Andrews, ZB, Burn, DJ & Davies, JS 2020, 'Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans', Cell Reports Medicine, vol. 1, no. 7, 100120, pp. 1-e9. https://doi.org/10.1016/j.xcrm.2020.100120

TY - JOUR

T1 - Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans

AU - Hornsby, Amanda K.E.

AU - Buntwal, Luke

AU - Carisi, Maria Carla

AU - Santos, Vanessa V.

AU - Johnston, Fionnuala

AU - Roberts, Luke D.

AU - Sassi, Martina

AU - Mequinion, Mathieu

AU - Stark, Romana

AU - Reichenbach, Alex

AU - Lockie, Sarah H.

AU - Siervo, Mario

AU - Howell, Owain

AU - Morgan, Alwena H.

AU - Wells, Timothy

AU - Andrews, Zane B.

AU - Burn, David J.

AU - Davies, Jeffrey S.

PY - 2020/10/20

Y1 - 2020/10/20

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AB - The gut-hormone acyl-ghrelin (AG) is known to promote adult hippocampal neurogenesis. Hornsby et al. combine in vitro and in vivo rodent models, alongside analysis of human plasma, to show that unacylated-ghrelin (UAG) impairs neurogenesis and that the circulating AG:UAG ratio is reduced in Parkinson's dementia.

KW - acyl-ghrelin

KW - adult hippocampal neurogenesis

KW - AG:UAG

KW - BDNF

KW - biomarker

KW - ghrelin

KW - GOAT

KW - memory

KW - Parkinson disease dementia

KW - unacylated-ghrelin

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DO - 10.1016/j.xcrm.2020.100120

M3 - Article

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AN - SCOPUS:85096545182

SN - 2666-3791

VL - 1

SP - 1-e9

JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 7

M1 - 100120

ER -

Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans

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Hunger-sensitive neural pathways influence appetite and behaviour

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Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans

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Hunger-sensitive neural pathways influence appetite and behaviour

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