Umbilical Cord Blood Cells for Perinatal Brain Injury

The Right Cells at the Right Time?

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Research

Abstract

Cerebral palsy (CP) is the most common cause of physical disability in children. CP currently has no cure and there are only few interventions to prevent the development of disability. There are four principal complications of pregnancy or birth that can damage the developing brain and lead to CP: preterm birth, fetal growth restriction, infection during pregnancy and severe hypoxia-ischemia at birth. Umbilical cord blood (UCB) cells are a very promising therapy for the treatment of CP. While UCB therapy for juveniles with CP is currently being assessed in clinical trials, very little is known about their mechanisms of action or which cells found in umbilical cord blood protect against and/or repair brain injury. In this chapter, we first explore the complications that can lead to perinatal brain injury. We then discuss the different cell types found in UCB and the specific properties that make each of them individually attractive therapeutic candidates for treatment of perinatal brain injury. While UCB holds much promise as a therapy for CP, it is imperative that more research is conducted to understand how the different cell types found in UCB can protect against brain injury in order to design more effective and targeted therapies.
Original languageEnglish
Title of host publicationUmbilical Cord Blood Banking for Clinical Application and Regenerative Medicine
EditorsAna Colette Mauricio
Place of PublicationRijeka Croatia
PublisherIn-Tech
Pages101-131
Number of pages31
ISBN (Electronic)9789535128663
ISBN (Print)9789535128656
DOIs
Publication statusPublished - 11 Jan 2017

Cite this

McDonald, C. A., Castillo-Melendez, M., Penny, T. R., Jenkin, G., & Miller, S. L. (2017). Umbilical Cord Blood Cells for Perinatal Brain Injury: The Right Cells at the Right Time? In A. C. Mauricio (Ed.), Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine (pp. 101-131). Rijeka Croatia: In-Tech. https://doi.org/10.5772/66647
McDonald, Courtney A. ; Castillo-Melendez, Margie ; Penny, Tayla R. ; Jenkin, Graham ; Miller, Suzanne L. / Umbilical Cord Blood Cells for Perinatal Brain Injury : The Right Cells at the Right Time?. Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine. editor / Ana Colette Mauricio. Rijeka Croatia : In-Tech, 2017. pp. 101-131
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McDonald, CA, Castillo-Melendez, M, Penny, TR, Jenkin, G & Miller, SL 2017, Umbilical Cord Blood Cells for Perinatal Brain Injury: The Right Cells at the Right Time? in AC Mauricio (ed.), Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine. In-Tech, Rijeka Croatia, pp. 101-131. https://doi.org/10.5772/66647

Umbilical Cord Blood Cells for Perinatal Brain Injury : The Right Cells at the Right Time? / McDonald, Courtney A.; Castillo-Melendez, Margie; Penny, Tayla R.; Jenkin, Graham; Miller, Suzanne L.

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine. ed. / Ana Colette Mauricio. Rijeka Croatia : In-Tech, 2017. p. 101-131.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Research

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AB - Cerebral palsy (CP) is the most common cause of physical disability in children. CP currently has no cure and there are only few interventions to prevent the development of disability. There are four principal complications of pregnancy or birth that can damage the developing brain and lead to CP: preterm birth, fetal growth restriction, infection during pregnancy and severe hypoxia-ischemia at birth. Umbilical cord blood (UCB) cells are a very promising therapy for the treatment of CP. While UCB therapy for juveniles with CP is currently being assessed in clinical trials, very little is known about their mechanisms of action or which cells found in umbilical cord blood protect against and/or repair brain injury. In this chapter, we first explore the complications that can lead to perinatal brain injury. We then discuss the different cell types found in UCB and the specific properties that make each of them individually attractive therapeutic candidates for treatment of perinatal brain injury. While UCB holds much promise as a therapy for CP, it is imperative that more research is conducted to understand how the different cell types found in UCB can protect against brain injury in order to design more effective and targeted therapies.

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McDonald CA, Castillo-Melendez M, Penny TR, Jenkin G, Miller SL. Umbilical Cord Blood Cells for Perinatal Brain Injury: The Right Cells at the Right Time? In Mauricio AC, editor, Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine. Rijeka Croatia: In-Tech. 2017. p. 101-131 https://doi.org/10.5772/66647