Ultratrace detection of glucose with enzyme-functionalized single nanochannels

Guanglei Hou, Huacheng Zhang, Ganhua Xie, Kai Xiao, Liping Wen, Shuhong Li, Ye Tian, Lei Jiang

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55 Citations (Scopus)


A sensitive nano-device for D-glucose detection is prepared by modifying a single conical polymer nanochannel with GOx enzymes. The current-voltage (I-V) characterization suggests that the nano-device responds to D-glucose rather than its enantiomer at concentrations down to 1 nM (10-9 mol L-1). Moreover, the nano-device exhibits good reproducibility and specificity for D-glucose and is an ideal candidate for commercial non-invasive blood glucose meters in the future.
Original languageEnglish
Pages (from-to)19131-19135
Number of pages5
JournalJournal of Materials Chemistry A
Issue number45
Publication statusPublished - 7 Dec 2014
Externally publishedYes

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