Ultratrace detection of glucose with enzyme-functionalized single nanochannels

Guanglei Hou; Huacheng Zhang; Ganhua Xie; Kai Xiao; Liping Wen; Shuhong Li; Ye Tian; Lei Jiang

doi:10.1039/c4ta05013d

Ultratrace detection of glucose with enzyme-functionalized single nanochannels

Guanglei Hou, Huacheng Zhang, Ganhua Xie, Kai Xiao, Liping Wen, Shuhong Li, Ye Tian, Lei Jiang

Research output: Contribution to journal › Article › Research › peer-review

61 Citations (Scopus)

Abstract

A sensitive nano-device for D-glucose detection is prepared by modifying a single conical polymer nanochannel with GOx enzymes. The current-voltage (I-V) characterization suggests that the nano-device responds to D-glucose rather than its enantiomer at concentrations down to 1 nM (10^-9 mol L^-1). Moreover, the nano-device exhibits good reproducibility and specificity for D-glucose and is an ideal candidate for commercial non-invasive blood glucose meters in the future.

Original language	English
Pages (from-to)	19131-19135
Number of pages	5
Journal	Journal of Materials Chemistry A
Volume	2
Issue number	45
DOIs	https://doi.org/10.1039/c4ta05013d
Publication status	Published - 7 Dec 2014
Externally published	Yes

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10.1039/c4ta05013d

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Cite this

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title = "Ultratrace detection of glucose with enzyme-functionalized single nanochannels",

abstract = "A sensitive nano-device for D-glucose detection is prepared by modifying a single conical polymer nanochannel with GOx enzymes. The current-voltage (I-V) characterization suggests that the nano-device responds to D-glucose rather than its enantiomer at concentrations down to 1 nM (10-9 mol L-1). Moreover, the nano-device exhibits good reproducibility and specificity for D-glucose and is an ideal candidate for commercial non-invasive blood glucose meters in the future.",

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AU - Hou, Guanglei

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AU - Xie, Ganhua

AU - Xiao, Kai

AU - Wen, Liping

AU - Li, Shuhong

AU - Tian, Ye

AU - Jiang, Lei

PY - 2014/12/7

Y1 - 2014/12/7

N2 - A sensitive nano-device for D-glucose detection is prepared by modifying a single conical polymer nanochannel with GOx enzymes. The current-voltage (I-V) characterization suggests that the nano-device responds to D-glucose rather than its enantiomer at concentrations down to 1 nM (10-9 mol L-1). Moreover, the nano-device exhibits good reproducibility and specificity for D-glucose and is an ideal candidate for commercial non-invasive blood glucose meters in the future.

AB - A sensitive nano-device for D-glucose detection is prepared by modifying a single conical polymer nanochannel with GOx enzymes. The current-voltage (I-V) characterization suggests that the nano-device responds to D-glucose rather than its enantiomer at concentrations down to 1 nM (10-9 mol L-1). Moreover, the nano-device exhibits good reproducibility and specificity for D-glucose and is an ideal candidate for commercial non-invasive blood glucose meters in the future.

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