Ultrasound cavitation as a green processing technique in the design and manufacture of pharmaceutical nanoemulsions in drug delivery system

Siah Ying Tang, Khang Wei Tan, Manickam Sivakumar

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

12 Citations (Scopus)

Abstract

In the pharmaceutical industry, nanoemulsion appears to be an alternative and new dosage form for sparingly water-soluble drugs, in which they allow efficacious treatment of a variety of pains and diseases. Encapsulation of those hydrophobic biopharmaceuticals in the form of nanoemulsions offers numerous advantages: sustained and targeted drug delivery, enhanced dosing requirement with more convenient dosage form, and improved patient compliance with reduced possible adverse side effects. In recent years, ultrasound cavitation technique has been emerged as an energy-efficient yet powerful emulsification tool as various pharmaceutical and cosmetic emulsions can easily be produced with a fraction of the applied energy needed for conventional devices. In particular, ultrasound cavitation, the formation, growth, and implosive collapse of microbubbles, is the main phenomenon responsible for the break-up of larger primary emulsion droplets into finer particle size. Overall, this formulation strategy with such energy-intensive power ultrasound has a significant promise in developing pharmaceutical nanoemulsions with favorable properties in drug delivery systems.

Original languageEnglish
Title of host publicationGreen Chemistry for Environmental Remediation
EditorsRashmi Sanghi, Vandana Singh
PublisherJohn Wiley & Sons
Pages153-208
Number of pages56
Edition1st
ISBN (Print)9780470943083
DOIs
Publication statusPublished - 10 Jan 2012
Externally publishedYes

Keywords

  • Cavitation
  • Microbubbles
  • Nanoemulsion
  • Nanotechnology
  • Pharmaceuticals
  • Ultrasound

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