Abstract
In the pharmaceutical industry, nanoemulsion appears to be an alternative and new dosage form for sparingly water-soluble drugs, in which they allow efficacious treatment of a variety of pains and diseases. Encapsulation of those hydrophobic biopharmaceuticals in the form of nanoemulsions offers numerous advantages: sustained and targeted drug delivery, enhanced dosing requirement with more convenient dosage form, and improved patient compliance with reduced possible adverse side effects. In recent years, ultrasound cavitation technique has been emerged as an energy-efficient yet powerful emulsification tool as various pharmaceutical and cosmetic emulsions can easily be produced with a fraction of the applied energy needed for conventional devices. In particular, ultrasound cavitation, the formation, growth, and implosive collapse of microbubbles, is the main phenomenon responsible for the break-up of larger primary emulsion droplets into finer particle size. Overall, this formulation strategy with such energy-intensive power ultrasound has a significant promise in developing pharmaceutical nanoemulsions with favorable properties in drug delivery systems.
Original language | English |
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Title of host publication | Green Chemistry for Environmental Remediation |
Editors | Rashmi Sanghi, Vandana Singh |
Publisher | John Wiley & Sons |
Pages | 153-208 |
Number of pages | 56 |
Edition | 1st |
ISBN (Print) | 9780470943083 |
DOIs | |
Publication status | Published - 10 Jan 2012 |
Externally published | Yes |
Keywords
- Cavitation
- Microbubbles
- Nanoemulsion
- Nanotechnology
- Pharmaceuticals
- Ultrasound