Ubiquitin Signaling to NF-κB

Natalie A Borg, Vishva M Dixit

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Nuclear factor-κB (NF-κB) proteins are a family of transcription factors that control the expression of genes in key cellular processes. As aberrant activation of NF-κB is linked to the pathogenesis of human diseases, it must be tightly regulated to ensure that an appropriate physiological outcome is achieved. One such regulatory mechanism, termed ubiquitination, involves the modification of preexisting proteins with ubiquitin, rapidly altering their fate. Ubiquitination events are intricately entwined in NF-κB signaling pathways, owing to the range of ubiquitin linkages available and the reversible nature of the modification. Here we present an overview of some of the best-characterized NF-κB signaling pathways, highlighting their regulation by ubiquitin-mediated events. We emphasize the role of ubiquitin ligases, deubiquitinases, and ubiquitin-binding molecules in regulating this crucial family of transcription factors, NF-κB.

Original languageEnglish
Title of host publicationEncyclopedia of Immunobiology
EditorsMichael J.H. Ratcliffe
PublisherAcademic Press
Pages51-64
Number of pages14
Volume3
ISBN (Print)9780080921525
DOIs
Publication statusPublished - 27 Apr 2016

Keywords

  • Deubiquitinase
  • IL-1R
  • NF-κB
  • RIG-I
  • TCR
  • TLR
  • TNFR
  • Ubiquitin
  • Ubiquitin ligase
  • Ubiquitin-binding domain

Cite this

Borg, N. A., & Dixit, V. M. (2016). Ubiquitin Signaling to NF-κB. In M. J. H. Ratcliffe (Ed.), Encyclopedia of Immunobiology (Vol. 3, pp. 51-64). Academic Press. https://doi.org/10.1016/B978-0-12-374279-7.11007-0
Borg, Natalie A ; Dixit, Vishva M. / Ubiquitin Signaling to NF-κB. Encyclopedia of Immunobiology. editor / Michael J.H. Ratcliffe. Vol. 3 Academic Press, 2016. pp. 51-64
@inbook{66ea20e8de84438a96c4c79e86aad5f8,
title = "Ubiquitin Signaling to NF-κB",
abstract = "Nuclear factor-κB (NF-κB) proteins are a family of transcription factors that control the expression of genes in key cellular processes. As aberrant activation of NF-κB is linked to the pathogenesis of human diseases, it must be tightly regulated to ensure that an appropriate physiological outcome is achieved. One such regulatory mechanism, termed ubiquitination, involves the modification of preexisting proteins with ubiquitin, rapidly altering their fate. Ubiquitination events are intricately entwined in NF-κB signaling pathways, owing to the range of ubiquitin linkages available and the reversible nature of the modification. Here we present an overview of some of the best-characterized NF-κB signaling pathways, highlighting their regulation by ubiquitin-mediated events. We emphasize the role of ubiquitin ligases, deubiquitinases, and ubiquitin-binding molecules in regulating this crucial family of transcription factors, NF-κB.",
keywords = "Deubiquitinase, IL-1R, NF-κB, RIG-I, TCR, TLR, TNFR, Ubiquitin, Ubiquitin ligase, Ubiquitin-binding domain",
author = "Borg, {Natalie A} and Dixit, {Vishva M}",
year = "2016",
month = "4",
day = "27",
doi = "10.1016/B978-0-12-374279-7.11007-0",
language = "English",
isbn = "9780080921525",
volume = "3",
pages = "51--64",
editor = "Ratcliffe, {Michael J.H.}",
booktitle = "Encyclopedia of Immunobiology",
publisher = "Academic Press",
address = "United States of America",

}

Borg, NA & Dixit, VM 2016, Ubiquitin Signaling to NF-κB. in MJH Ratcliffe (ed.), Encyclopedia of Immunobiology. vol. 3, Academic Press, pp. 51-64. https://doi.org/10.1016/B978-0-12-374279-7.11007-0

Ubiquitin Signaling to NF-κB. / Borg, Natalie A; Dixit, Vishva M.

Encyclopedia of Immunobiology. ed. / Michael J.H. Ratcliffe. Vol. 3 Academic Press, 2016. p. 51-64.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

TY - CHAP

T1 - Ubiquitin Signaling to NF-κB

AU - Borg, Natalie A

AU - Dixit, Vishva M

PY - 2016/4/27

Y1 - 2016/4/27

N2 - Nuclear factor-κB (NF-κB) proteins are a family of transcription factors that control the expression of genes in key cellular processes. As aberrant activation of NF-κB is linked to the pathogenesis of human diseases, it must be tightly regulated to ensure that an appropriate physiological outcome is achieved. One such regulatory mechanism, termed ubiquitination, involves the modification of preexisting proteins with ubiquitin, rapidly altering their fate. Ubiquitination events are intricately entwined in NF-κB signaling pathways, owing to the range of ubiquitin linkages available and the reversible nature of the modification. Here we present an overview of some of the best-characterized NF-κB signaling pathways, highlighting their regulation by ubiquitin-mediated events. We emphasize the role of ubiquitin ligases, deubiquitinases, and ubiquitin-binding molecules in regulating this crucial family of transcription factors, NF-κB.

AB - Nuclear factor-κB (NF-κB) proteins are a family of transcription factors that control the expression of genes in key cellular processes. As aberrant activation of NF-κB is linked to the pathogenesis of human diseases, it must be tightly regulated to ensure that an appropriate physiological outcome is achieved. One such regulatory mechanism, termed ubiquitination, involves the modification of preexisting proteins with ubiquitin, rapidly altering their fate. Ubiquitination events are intricately entwined in NF-κB signaling pathways, owing to the range of ubiquitin linkages available and the reversible nature of the modification. Here we present an overview of some of the best-characterized NF-κB signaling pathways, highlighting their regulation by ubiquitin-mediated events. We emphasize the role of ubiquitin ligases, deubiquitinases, and ubiquitin-binding molecules in regulating this crucial family of transcription factors, NF-κB.

KW - Deubiquitinase

KW - IL-1R

KW - NF-κB

KW - RIG-I

KW - TCR

KW - TLR

KW - TNFR

KW - Ubiquitin

KW - Ubiquitin ligase

KW - Ubiquitin-binding domain

UR - http://www.scopus.com/inward/record.url?scp=85043282239&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374279-7.11007-0

DO - 10.1016/B978-0-12-374279-7.11007-0

M3 - Chapter (Book)

AN - SCOPUS:85043282239

SN - 9780080921525

VL - 3

SP - 51

EP - 64

BT - Encyclopedia of Immunobiology

A2 - Ratcliffe, Michael J.H.

PB - Academic Press

ER -

Borg NA, Dixit VM. Ubiquitin Signaling to NF-κB. In Ratcliffe MJH, editor, Encyclopedia of Immunobiology. Vol. 3. Academic Press. 2016. p. 51-64 https://doi.org/10.1016/B978-0-12-374279-7.11007-0