Typhoid fever: Pathogenesis and disease

Deborah House, Anne Bishop, Christopher Parry, Gordon Dougan, John Wain

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Typhoid fever is an infectious disease of global distribution. Although there is a wealth of data on Salmonella typhimurium infection in the mouse and the interaction of this serovar with human cell lines in vitro, there is a relatively small amount of data on S. typhi and the pathogenesis of typhoid fever. In this review we focus on three areas: adherence to and invasion of gut epithelial cells, dissemination to systemic sites, and survival and replication within host cells. In addition, we attempt to put current salmonella research into the context of typhoid fever.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalCurrent Opinion in Infectious Diseases
Volume14
Issue number5
DOIs
Publication statusPublished - 1 Jan 2001
Externally publishedYes

Cite this

House, Deborah ; Bishop, Anne ; Parry, Christopher ; Dougan, Gordon ; Wain, John. / Typhoid fever : Pathogenesis and disease. In: Current Opinion in Infectious Diseases. 2001 ; Vol. 14, No. 5. pp. 573-578.
@article{16f5d4a3089d490592d4246668ba8edb,
title = "Typhoid fever: Pathogenesis and disease",
abstract = "Typhoid fever is an infectious disease of global distribution. Although there is a wealth of data on Salmonella typhimurium infection in the mouse and the interaction of this serovar with human cell lines in vitro, there is a relatively small amount of data on S. typhi and the pathogenesis of typhoid fever. In this review we focus on three areas: adherence to and invasion of gut epithelial cells, dissemination to systemic sites, and survival and replication within host cells. In addition, we attempt to put current salmonella research into the context of typhoid fever.",
author = "Deborah House and Anne Bishop and Christopher Parry and Gordon Dougan and John Wain",
year = "2001",
month = "1",
day = "1",
doi = "10.1097/00001432-200110000-00011",
language = "English",
volume = "14",
pages = "573--578",
journal = "Current Opinion in Infectious Diseases",
issn = "0951-7375",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

Typhoid fever : Pathogenesis and disease. / House, Deborah; Bishop, Anne; Parry, Christopher; Dougan, Gordon; Wain, John.

In: Current Opinion in Infectious Diseases, Vol. 14, No. 5, 01.01.2001, p. 573-578.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Typhoid fever

T2 - Pathogenesis and disease

AU - House, Deborah

AU - Bishop, Anne

AU - Parry, Christopher

AU - Dougan, Gordon

AU - Wain, John

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Typhoid fever is an infectious disease of global distribution. Although there is a wealth of data on Salmonella typhimurium infection in the mouse and the interaction of this serovar with human cell lines in vitro, there is a relatively small amount of data on S. typhi and the pathogenesis of typhoid fever. In this review we focus on three areas: adherence to and invasion of gut epithelial cells, dissemination to systemic sites, and survival and replication within host cells. In addition, we attempt to put current salmonella research into the context of typhoid fever.

AB - Typhoid fever is an infectious disease of global distribution. Although there is a wealth of data on Salmonella typhimurium infection in the mouse and the interaction of this serovar with human cell lines in vitro, there is a relatively small amount of data on S. typhi and the pathogenesis of typhoid fever. In this review we focus on three areas: adherence to and invasion of gut epithelial cells, dissemination to systemic sites, and survival and replication within host cells. In addition, we attempt to put current salmonella research into the context of typhoid fever.

UR - http://www.scopus.com/inward/record.url?scp=0034815729&partnerID=8YFLogxK

U2 - 10.1097/00001432-200110000-00011

DO - 10.1097/00001432-200110000-00011

M3 - Review Article

VL - 14

SP - 573

EP - 578

JO - Current Opinion in Infectious Diseases

JF - Current Opinion in Infectious Diseases

SN - 0951-7375

IS - 5

ER -