Typhoid fever in Dhulikhel hospital, Nepal.

N. Sharma, R. Koju, B. Karmacharya, M. D. Tamang, R. Makaju, N. Nepali, P. Shrestha, D. Adhikari

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One hundred and twelve cases of typhoid fever presenting in outpatient and emergency department of Dhulikhel Hospital in Nepal were studied. In this study, it was found that 71% typhoid fever cases were less than 30 years of age group with male to female ratio of 3:1. Fever over 5 days followed by headache and chills were major presenting symptoms. Widal test and blood culture for Salmonella typhi were positive in 59% and 49% cases respectively. Two third of our study population had total leucocyte count of normal range. The fever clearance time was significantly better with ofloxacin compared to ciprofloxacin (p < 0.05) and ceftriaxone compared to chloramphenicol (p < 0.05). The release from treatment was significantly shorter with ceftriaxone compared to ofloxacin, ciprofloxacin and chloramphenicol (p < 0.01). Ceftriaxone was found to be 100% sensitive to salmonella typhi. Amoxicillin was only 52.1% sensitive to Salmonella typhi. Early diagnosis and institution of appropriate antibiotic therapy is of paramount importance in the management of typhoid patients.

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalKathmandu University Medical Journal
Issue number3
Publication statusPublished - 1 Jul 2004
Externally publishedYes

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