Type II toxin

antitoxin systems. More than small selfish entities?

Andrea Rocker, Anton Meinhart

Research output: Contribution to journalReview ArticleOtherpeer-review

27 Citations (Scopus)

Abstract

Toxin–antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins. However, evidence is increasing that the toxins are much more diverse and can form multi-domain proteins. Recently, we published a novel type II TA system in which toxin and antitoxin are covalently linked into a single polypeptide chain. In this review we summarize the current knowledge on these elongated toxin homologs and provide perspectives for future study.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalCurrent Genetics
Volume62
Issue number2
DOIs
Publication statusPublished - 1 May 2016
Externally publishedYes

Keywords

  • Elongated toxin
  • Fusion
  • Multi-domain protein
  • Toxin–antitoxin system

Cite this

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title = "Type II toxin: antitoxin systems. More than small selfish entities?",
abstract = "Toxin–antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins. However, evidence is increasing that the toxins are much more diverse and can form multi-domain proteins. Recently, we published a novel type II TA system in which toxin and antitoxin are covalently linked into a single polypeptide chain. In this review we summarize the current knowledge on these elongated toxin homologs and provide perspectives for future study.",
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Type II toxin : antitoxin systems. More than small selfish entities? / Rocker, Andrea; Meinhart, Anton.

In: Current Genetics, Vol. 62, No. 2, 01.05.2016, p. 287-290.

Research output: Contribution to journalReview ArticleOtherpeer-review

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T2 - antitoxin systems. More than small selfish entities?

AU - Rocker, Andrea

AU - Meinhart, Anton

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Toxin–antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins. However, evidence is increasing that the toxins are much more diverse and can form multi-domain proteins. Recently, we published a novel type II TA system in which toxin and antitoxin are covalently linked into a single polypeptide chain. In this review we summarize the current knowledge on these elongated toxin homologs and provide perspectives for future study.

AB - Toxin–antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins. However, evidence is increasing that the toxins are much more diverse and can form multi-domain proteins. Recently, we published a novel type II TA system in which toxin and antitoxin are covalently linked into a single polypeptide chain. In this review we summarize the current knowledge on these elongated toxin homologs and provide perspectives for future study.

KW - Elongated toxin

KW - Fusion

KW - Multi-domain protein

KW - Toxin–antitoxin system

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DO - 10.1007/s00294-015-0541-7

M3 - Review Article

VL - 62

SP - 287

EP - 290

JO - Current Genetics

JF - Current Genetics

SN - 0172-8083

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