Type I Interferons and the Perpetuation of a Loss of Tolerance

Kathryn Connelly; Alberta Hoi

doi:10.1007/978-3-030-85161-3_4

Type I Interferons and the Perpetuation of a Loss of Tolerance

Kathryn Connelly, Alberta Hoi

Medicine Monash Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Abstract

Dysregulation of the type I interferon (IFN) system has emerged as a key pathway involved in the perpetuation of autoimmunity and inflammation in systemic lupus erythematosus (SLE). As our understanding of this pathway and its role in disease continues to grow, clinical application through type I IFN based disease biomarkers and targeted therapeutics are emerging. This is the first of two chapters covering the role of type I interferons in lupus and will focus on the basics of the type I IFN system, in particular the role of IFN alpha produced by plasmacytoid dendritic cells and relevant downstream effects that can contribute to the initiation and propagation of immune pathology in SLE.

Original language	English
Title of host publication	Pathogenesis of Systemic Lupus Erythematosus
Subtitle of host publication	Insights from Translational Research
Editors	Alberta Hoi
Place of Publication	Cham Switzerland
Publisher	Springer
Chapter	4
Pages	53-65
Number of pages	13
ISBN (Electronic)	9783030851613
ISBN (Print)	9783030851606
DOIs	https://doi.org/10.1007/978-3-030-85161-3_4
Publication status	Published - 2021

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10.1007/978-3-030-85161-3_4

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abstract = "Dysregulation of the type I interferon (IFN) system has emerged as a key pathway involved in the perpetuation of autoimmunity and inflammation in systemic lupus erythematosus (SLE). As our understanding of this pathway and its role in disease continues to grow, clinical application through type I IFN based disease biomarkers and targeted therapeutics are emerging. This is the first of two chapters covering the role of type I interferons in lupus and will focus on the basics of the type I IFN system, in particular the role of IFN alpha produced by plasmacytoid dendritic cells and relevant downstream effects that can contribute to the initiation and propagation of immune pathology in SLE.",

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N2 - Dysregulation of the type I interferon (IFN) system has emerged as a key pathway involved in the perpetuation of autoimmunity and inflammation in systemic lupus erythematosus (SLE). As our understanding of this pathway and its role in disease continues to grow, clinical application through type I IFN based disease biomarkers and targeted therapeutics are emerging. This is the first of two chapters covering the role of type I interferons in lupus and will focus on the basics of the type I IFN system, in particular the role of IFN alpha produced by plasmacytoid dendritic cells and relevant downstream effects that can contribute to the initiation and propagation of immune pathology in SLE.

AB - Dysregulation of the type I interferon (IFN) system has emerged as a key pathway involved in the perpetuation of autoimmunity and inflammation in systemic lupus erythematosus (SLE). As our understanding of this pathway and its role in disease continues to grow, clinical application through type I IFN based disease biomarkers and targeted therapeutics are emerging. This is the first of two chapters covering the role of type I interferons in lupus and will focus on the basics of the type I IFN system, in particular the role of IFN alpha produced by plasmacytoid dendritic cells and relevant downstream effects that can contribute to the initiation and propagation of immune pathology in SLE.

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Type I Interferons and the Perpetuation of a Loss of Tolerance

Abstract

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Pathogenesis of Systemic Lupus Erythematosus: Insights from Translational Research

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