TY - JOUR
T1 - Type 1 conventional dendritic cells
T2 - ontogeny, function, and emerging roles in cancer immunotherapy
AU - Zhang, Shengbo
AU - Chopin, Michaël
AU - Nutt, Stephen L.
N1 - Funding Information:
We thank Andrew Lew for critical reading of this manuscript. This work was supported by the National Health and Medical Research Council of Australia grants; 1196235 (M.C.) 1155342 (S.L.N.), and the Melbourne research scholarship (S.Z.). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIIS.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/12
Y1 - 2021/12
N2 - Dendritic cells (DCs) are key immune sentinels that orchestrate protective immune responses against pathogens or cancers. DCs have evolved into multiple phenotypically, anatomically, and functionally distinct cell types. One of these DC types, Type 1 conventional DCs (cDC1s), are uniquely equipped to promote cytotoxic CD8+ T cell differentiation and, therefore, represent a promising target for harnessing antitumor immunity. Indeed, recent studies have highlighted the importance of cDC1s in tumor immunotherapy using immune checkpoint inhibitors. Here, we review the progress in defining the key developmental and functional attributes of cDC1s and the approaches to optimizing the potency of cDC1s for anticancer immunity.
AB - Dendritic cells (DCs) are key immune sentinels that orchestrate protective immune responses against pathogens or cancers. DCs have evolved into multiple phenotypically, anatomically, and functionally distinct cell types. One of these DC types, Type 1 conventional DCs (cDC1s), are uniquely equipped to promote cytotoxic CD8+ T cell differentiation and, therefore, represent a promising target for harnessing antitumor immunity. Indeed, recent studies have highlighted the importance of cDC1s in tumor immunotherapy using immune checkpoint inhibitors. Here, we review the progress in defining the key developmental and functional attributes of cDC1s and the approaches to optimizing the potency of cDC1s for anticancer immunity.
KW - antigen presentation
KW - cytokines
KW - myelopoiesis
KW - transcription
KW - tumor immunity
UR - http://www.scopus.com/inward/record.url?scp=85118335426&partnerID=8YFLogxK
U2 - 10.1016/j.it.2021.10.004
DO - 10.1016/j.it.2021.10.004
M3 - Review Article
C2 - 34728143
AN - SCOPUS:85118335426
SN - 1471-4906
VL - 42
SP - 1113
EP - 1127
JO - Trends in Immunology
JF - Trends in Immunology
IS - 12
ER -
