Two ATM variants and breast cancer risk

Deborah Thompson, Antonis C. Antoniou, Mark Jenkins, Anna Marsh, Xiaoqing Chen, Tierney Wayne, Andrea Tesoriero, Roger Milne, Amanda Spurdle, Yvonne Thorstenson, Melissa Southey, Graham G. Giles, kConFab Investigators, Kum Kum Khanna, Joseph Sambrook, Peter Oefner, David Goldgar, John L. Hopper, Doug Easton, Georgia Chenevix-Trench

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Abstract

The ATM gene is mutated in ataxia-telangiectasia (AT). Heterozygote female relatives of AT cases have a 2-7fold increased risk of breast cancer. We previously reported high risks of breast cancer associated with certain ATM variants. To estimate the risks more precisely, we have examined two ATM variants, c.1066-6T>G (IVS10-6T>G) and c.4258C>T (p.Leu1420Phe), in additional cases and controls from the same Australian cohorts previously used to estimate the risk of breast cancer associated with c.1066-6T>G. A total of 775 and 84 population-based controls were genotyped for the c.1066-6T>G and c.4258C>T ATM variants respectively, as were index cases from 378 and 373 non-BRCA1/2 breast cancer families. Penetrance was estimated by Bayes factor analysis. The allele frequencies of ATM c.1066-6T>G and c.4258C>T estimated from controls were 0.005 (95% CI=0.002 to 0.009) and 0.012 (95% CI=0.001 to 0.042), respectively. We identified three new breast cancer families with c.1066-6T>G, and seven families with c.4258C>T. Combining with the two c.1066-6T>G families previously reported, the estimated penetrance to age 70 of c.1066-6T>G was 17.2% (95% CI=4.7% to 37.5%). For c.4258C>T, the estimated average penetrance was 4.8% (95% CI 1.7% to 10.1%). In conclusion, we found no evidence that the ATM c.4258C>T variant increases breast cancer risk, and little evidence that c.1066-6T>G confers an elevated risk. Analysis of additional families will be necessary to define more precisely the risk, if any, associated with c.1066-6T>G.

Original languageEnglish
Number of pages10
JournalHuman Mutation
Volume25
Issue number6
DOIs
Publication statusPublished - 1 Jan 2005
Externally publishedYes

Cite this

Thompson, D., Antoniou, A. C., Jenkins, M., Marsh, A., Chen, X., Wayne, T., Tesoriero, A., Milne, R., Spurdle, A., Thorstenson, Y., Southey, M., Giles, G. G., kConFab Investigators, Khanna, K. K., Sambrook, J., Oefner, P., Goldgar, D., Hopper, J. L., Easton, D., & Chenevix-Trench, G. (2005). Two ATM variants and breast cancer risk. Human Mutation, 25(6). https://doi.org/10.1002/humu.9344