TY - JOUR
T1 - Twenty-seven-year time trends in dementia incidence in Europe and the United States
T2 - The Alzheimer Cohorts Consortium
AU - Wolters, Frank J.
AU - Chibnik, Lori B
AU - Waziry, Reem
AU - Anderson, Roy
AU - Berr, Claudine
AU - Beiser, Alexa
AU - Bis, Joshua C
AU - Blacker, Deborah
AU - Bos, Daniel
AU - Brayne, Carol
AU - Dartigues, Jean-Francois
AU - Darweesh, Sirwan KL
AU - Davis-Plourde, Kendra L
AU - de Wolf, Frank
AU - Debette, Stephanie
AU - Dufouil, Carole
AU - Fornage, Myriam
AU - Goudsmit, Jaap
AU - Grasset, Leslie
AU - Gudnason, Vilmundur
AU - Pase, Matthew P.
PY - 2020/8/4
Y1 - 2020/8/4
N2 - OBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. RESULTS: Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65-69 years to 65 per 1,000 person-years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] vs 8% [0%-15%]). CONCLUSION: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.
AB - OBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. RESULTS: Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65-69 years to 65 per 1,000 person-years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] vs 8% [0%-15%]). CONCLUSION: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.
UR - http://www.scopus.com/inward/record.url?scp=85089127421&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000010022
DO - 10.1212/WNL.0000000000010022
M3 - Article
C2 - 32611641
AN - SCOPUS:85089127421
SN - 0028-3878
VL - 95
SP - e519-e531
JO - Neurology
JF - Neurology
IS - 5
ER -