Turning the corner in fertility: High DNA integrity of boundary-following sperm

Lise Eamer; Marion Vollmer; Reza Nosrati; Maria C. San Gabriel; Krista Zeidan; Armand Zini; David Sinton

doi:10.1039/c6lc00490c

Turning the corner in fertility: High DNA integrity of boundary-following sperm

Lise Eamer, Marion Vollmer, Reza Nosrati, Maria C. San Gabriel, Krista Zeidan, Armand Zini, David Sinton

Research output: Contribution to journal › Article › Research › peer-review

50 Citations (Scopus)

Abstract

We present a passive microfluidic sperm selection strategy that collects motile sperm based on their preference to follow boundaries and turn corners. Clinical assessment of selected human sperm from the device revealed a strong correlation between high DNA integrity and the tendency for sperm to follow boundaries. Human sperm with preference to follow boundaries on the left- or right-hand sides have higher (>51%) DNA integrity than straight swimmers and significantly higher (>67%) DNA integrity than sperm in raw semen. Boundary following behaviour offers a strategy to selecting sperm with the highest DNA integrity to improve the success rate of assisted reproduction.

Original language	English
Pages (from-to)	2418-2422
Number of pages	5
Journal	Lab on a Chip
Volume	16
Issue number	13
DOIs	https://doi.org/10.1039/c6lc00490c
Publication status	Published - 1 Jan 2016
Externally published	Yes

Access to Document

10.1039/c6lc00490c

Cite this

@article{5e0d583af817450b9b5a959275636e39,

title = "Turning the corner in fertility: High DNA integrity of boundary-following sperm",

abstract = "We present a passive microfluidic sperm selection strategy that collects motile sperm based on their preference to follow boundaries and turn corners. Clinical assessment of selected human sperm from the device revealed a strong correlation between high DNA integrity and the tendency for sperm to follow boundaries. Human sperm with preference to follow boundaries on the left- or right-hand sides have higher (>51%) DNA integrity than straight swimmers and significantly higher (>67%) DNA integrity than sperm in raw semen. Boundary following behaviour offers a strategy to selecting sperm with the highest DNA integrity to improve the success rate of assisted reproduction.",

author = "Lise Eamer and Marion Vollmer and Reza Nosrati and {San Gabriel}, {Maria C.} and Krista Zeidan and Armand Zini and David Sinton",

year = "2016",

month = jan,

day = "1",

doi = "10.1039/c6lc00490c",

language = "English",

volume = "16",

pages = "2418--2422",

journal = "Lab on a Chip",

issn = "1473-0197",

publisher = "The Royal Society of Chemistry",

number = "13",

}

TY - JOUR

T1 - Turning the corner in fertility

T2 - High DNA integrity of boundary-following sperm

AU - Eamer, Lise

AU - Vollmer, Marion

AU - Nosrati, Reza

AU - San Gabriel, Maria C.

AU - Zeidan, Krista

AU - Zini, Armand

AU - Sinton, David

PY - 2016/1/1

Y1 - 2016/1/1

N2 - We present a passive microfluidic sperm selection strategy that collects motile sperm based on their preference to follow boundaries and turn corners. Clinical assessment of selected human sperm from the device revealed a strong correlation between high DNA integrity and the tendency for sperm to follow boundaries. Human sperm with preference to follow boundaries on the left- or right-hand sides have higher (>51%) DNA integrity than straight swimmers and significantly higher (>67%) DNA integrity than sperm in raw semen. Boundary following behaviour offers a strategy to selecting sperm with the highest DNA integrity to improve the success rate of assisted reproduction.

AB - We present a passive microfluidic sperm selection strategy that collects motile sperm based on their preference to follow boundaries and turn corners. Clinical assessment of selected human sperm from the device revealed a strong correlation between high DNA integrity and the tendency for sperm to follow boundaries. Human sperm with preference to follow boundaries on the left- or right-hand sides have higher (>51%) DNA integrity than straight swimmers and significantly higher (>67%) DNA integrity than sperm in raw semen. Boundary following behaviour offers a strategy to selecting sperm with the highest DNA integrity to improve the success rate of assisted reproduction.

UR - http://www.scopus.com/inward/record.url?scp=84975818534&partnerID=8YFLogxK

U2 - 10.1039/c6lc00490c

DO - 10.1039/c6lc00490c

M3 - Article

C2 - 27241827

AN - SCOPUS:84975818534

SN - 1473-0197

VL - 16

SP - 2418

EP - 2422

JO - Lab on a Chip

JF - Lab on a Chip

IS - 13

ER -

Turning the corner in fertility: High DNA integrity of boundary-following sperm

Abstract

Access to Document

Other files and links

Cite this