Turning the corner in fertility: High DNA integrity of boundary-following sperm

Lise Eamer, Marion Vollmer, Reza Nosrati, Maria C. San Gabriel, Krista Zeidan, Armand Zini, David Sinton

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

We present a passive microfluidic sperm selection strategy that collects motile sperm based on their preference to follow boundaries and turn corners. Clinical assessment of selected human sperm from the device revealed a strong correlation between high DNA integrity and the tendency for sperm to follow boundaries. Human sperm with preference to follow boundaries on the left- or right-hand sides have higher (>51%) DNA integrity than straight swimmers and significantly higher (>67%) DNA integrity than sperm in raw semen. Boundary following behaviour offers a strategy to selecting sperm with the highest DNA integrity to improve the success rate of assisted reproduction.

Original languageEnglish
Pages (from-to)2418-2422
Number of pages5
JournalLab on a Chip
Volume16
Issue number13
DOIs
Publication statusPublished - 1 Jan 2016
Externally publishedYes

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