Tunable thermo-responsive polymer-protein conjugates via a combination of nucleophilic thiol-ene "click" and SET-LRP

Mathew W. Jones; Matthew I. Gibson; Giuseppe Mantovani; David M. Haddleton

doi:10.1039/c0py00329h

Tunable thermo-responsive polymer-protein conjugates via a combination of nucleophilic thiol-ene "click" and SET-LRP

Mathew W. Jones, Matthew I. Gibson, Giuseppe Mantovani, David M. Haddleton

Research output: Contribution to journal › Article › Research › peer-review

84 Citations (Scopus)

Abstract

Herein we report the synthesis of a protein macroinitiator in a one-pot strategy using phosphine-mediated thiol-ene "click", the macroinitiator was used to polymerise ethylene glycol containing monomers to yield polymer-protein conjugates with tunable thermoresponsive behaviour.

Original language	English
Pages (from-to)	572-574
Number of pages	3
Journal	Polymer Chemistry
Volume	2
Issue number	3
DOIs	https://doi.org/10.1039/c0py00329h
Publication status	Published - Mar 2011
Externally published	Yes

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abstract = "Herein we report the synthesis of a protein macroinitiator in a one-pot strategy using phosphine-mediated thiol-ene {"}click{"}, the macroinitiator was used to polymerise ethylene glycol containing monomers to yield polymer-protein conjugates with tunable thermoresponsive behaviour.",

author = "Jones, \{Mathew W.\} and Gibson, \{Matthew I.\} and Giuseppe Mantovani and Haddleton, \{David M.\}",

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AU - Gibson, Matthew I.

AU - Mantovani, Giuseppe

AU - Haddleton, David M.

PY - 2011/3

Y1 - 2011/3

N2 - Herein we report the synthesis of a protein macroinitiator in a one-pot strategy using phosphine-mediated thiol-ene "click", the macroinitiator was used to polymerise ethylene glycol containing monomers to yield polymer-protein conjugates with tunable thermoresponsive behaviour.

AB - Herein we report the synthesis of a protein macroinitiator in a one-pot strategy using phosphine-mediated thiol-ene "click", the macroinitiator was used to polymerise ethylene glycol containing monomers to yield polymer-protein conjugates with tunable thermoresponsive behaviour.

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U2 - 10.1039/c0py00329h

DO - 10.1039/c0py00329h

M3 - Article

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EP - 574

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 3

ER -

Tunable thermo-responsive polymer-protein conjugates via a combination of nucleophilic thiol-ene "click" and SET-LRP

Abstract

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