TY - JOUR
T1 - Tunable electrochemical behavior of dicarboxylic acids anchored Co-MOF
T2 - Sensitive determination of rutin in pharmaceutical samples
AU - Sivam, Thushatharcchini
AU - Gowthaman, N. S.K.
AU - Lim, H. N.
AU - Andou, Yoshito
AU - Arul, P.
AU - Narayanamoorthi, E.
AU - John, S. Abraham
N1 - Funding Information:
This research was supported by Universiti Putra Malaysia under Geran Putra Berimpak ( UPM/800-3/3/3/Geran Putra Berimpak ). EN and SAJ thank the financial support from DST-SERB ( EMR/2016/002898 ), New Delhi, India.
Publisher Copyright:
© 2021 Elsevier B.V.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/8/5
Y1 - 2021/8/5
N2 - Rutin (RT) also known as vitamin P, is an electroactive flavanoid mainly found in plants. It is generally applied as a clinical drug, Chinese traditional medicine and consumed as a supplement and act as a healthy collagen. Consumption of RT as supplement associated with some side effects and certain people has allergy towards RT. Therefore, it is meaningful to develop a fast, simple and reliable method to detect RT to avoid health risks. This paper describes the facile synthesis of Co-MOF using 1,4-benzenedicarboxylic acid (BDC) and biphenyl-4,4-dicarboxylic acid (BPDC) as ligands through solvothermal method. The XRD patterns and FT-IR spectra confirm the formation of Co-BDC and Co-BPDC MOFs. Moreover, the SEM images revealed that the Co-BDC MOF possesses a stacked layer of MOF while Co-BPDC MOF shows a flower-like MOF. The Co-BDC and Co-BPDC MOFs were fabricated on GC electrode for the sensitive determination of RT. The ligands with different chain lengths in the MOFs have influenced the interaction of RT with the MOF. The Co-BPDC-MOF/GCE exhibited an excellent electrocatalytic activity than the Co-BDC-MOF/GCE and the fabricated electrode was successfully utilized for the determination of RT in pharmaceutical samples. The fabricated sensor exhibited the limit of detection of 0.03 µM (S/N = 3) and the superior sensitivity of 781.43 µA/mM/cm2 in the linear range detection of 0.5 – 1000 µM RT with excellent repeatability, reproducibility, and good anti-interference ability.
AB - Rutin (RT) also known as vitamin P, is an electroactive flavanoid mainly found in plants. It is generally applied as a clinical drug, Chinese traditional medicine and consumed as a supplement and act as a healthy collagen. Consumption of RT as supplement associated with some side effects and certain people has allergy towards RT. Therefore, it is meaningful to develop a fast, simple and reliable method to detect RT to avoid health risks. This paper describes the facile synthesis of Co-MOF using 1,4-benzenedicarboxylic acid (BDC) and biphenyl-4,4-dicarboxylic acid (BPDC) as ligands through solvothermal method. The XRD patterns and FT-IR spectra confirm the formation of Co-BDC and Co-BPDC MOFs. Moreover, the SEM images revealed that the Co-BDC MOF possesses a stacked layer of MOF while Co-BPDC MOF shows a flower-like MOF. The Co-BDC and Co-BPDC MOFs were fabricated on GC electrode for the sensitive determination of RT. The ligands with different chain lengths in the MOFs have influenced the interaction of RT with the MOF. The Co-BPDC-MOF/GCE exhibited an excellent electrocatalytic activity than the Co-BDC-MOF/GCE and the fabricated electrode was successfully utilized for the determination of RT in pharmaceutical samples. The fabricated sensor exhibited the limit of detection of 0.03 µM (S/N = 3) and the superior sensitivity of 781.43 µA/mM/cm2 in the linear range detection of 0.5 – 1000 µM RT with excellent repeatability, reproducibility, and good anti-interference ability.
KW - Co-BDC-MOF
KW - Co-BPDC-MOF
KW - Electrochemical sensor
KW - Metal-organic framework
KW - Pharmaceutical samples
KW - Rutin
UR - http://www.scopus.com/inward/record.url?scp=85105355287&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfa.2021.126667
DO - 10.1016/j.colsurfa.2021.126667
M3 - Article
AN - SCOPUS:85105355287
VL - 622
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects
SN - 0927-7757
M1 - 126667
ER -