Tumour stroma control of human prostate cancer stem cells

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Prostate cancer is an epithelial malignancy and stem cells are a major focus of current research efforts. This is a warranted approach, since the processes of self-renewal and differentiation underpin the fundamental biology of malignancy and cancer recurrence due to therapeutic resistance. In this chapter, we review the regulation of stem cells through reciprocal interaction with the surrounding microenvironment. In both normal tissues and in prostate cancer, stem cells are controlled by both intrinsic and extrinsic mechanisms, the latter involving stromal directed stem cell differentiation. Herein, we discuss the current experimental models to study stromal-stem cell interaction and present the current knowledge on how the two cellular compartments should be considered in unison to design more effective therapies for clinical management of prostate cancer.
Original languageEnglish
Title of host publicationStem Cells and Prostate Cancer
EditorsScott D Cramer
Place of PublicationUSA
PublisherSpringer
Pages111 - 126
Number of pages16
Edition1st
ISBN (Print)9781461464976
DOIs
Publication statusPublished - 2013

Cite this

Risbridger, G. P., & Taylor, R. A. (2013). Tumour stroma control of human prostate cancer stem cells. In S. D. Cramer (Ed.), Stem Cells and Prostate Cancer (1st ed., pp. 111 - 126). USA: Springer. https://doi.org/10.1007/978-1-4614-6498-3_7
Risbridger, Gail Petuna ; Taylor, Renea Anne. / Tumour stroma control of human prostate cancer stem cells. Stem Cells and Prostate Cancer. editor / Scott D Cramer. 1st. ed. USA : Springer, 2013. pp. 111 - 126
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Risbridger, GP & Taylor, RA 2013, Tumour stroma control of human prostate cancer stem cells. in SD Cramer (ed.), Stem Cells and Prostate Cancer. 1st edn, Springer, USA, pp. 111 - 126. https://doi.org/10.1007/978-1-4614-6498-3_7

Tumour stroma control of human prostate cancer stem cells. / Risbridger, Gail Petuna; Taylor, Renea Anne.

Stem Cells and Prostate Cancer. ed. / Scott D Cramer. 1st. ed. USA : Springer, 2013. p. 111 - 126.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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Risbridger GP, Taylor RA. Tumour stroma control of human prostate cancer stem cells. In Cramer SD, editor, Stem Cells and Prostate Cancer. 1st ed. USA: Springer. 2013. p. 111 - 126 https://doi.org/10.1007/978-1-4614-6498-3_7