Tumour associated epilepsy and glutamate excitotoxicity in patients with gliomas

Simon V. Liubinas, Terence J. O'Brien, Bradford M. Moffat, Katharine J. Drummond, Andrew P. Morokoff, Andrew H. Kaye

Research output: Contribution to journalReview ArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Tumour associated epilepsy (TAE) is common, debilitating and often not successfully controlled by surgical resection of the tumour and administration of multiple anti-epileptic drugs. It represents a cause of significant lost quality of life in an incurable disease and is therefore an important subject for ongoing research. The pathogenesis of TAE is likely to be multifactorial and involve, on the microscopic level, the interaction of genetic factors, changes in the peritumoural microenvironment, alterations in synaptic neurotransmitter release and re-uptake, and the excitotoxic effects of glutamate. On a macroscopic level, the occurrence of TAE is likely to be influenced by tumour size, location and interaction with environmental factors. The optimal treatment of TAE requires a multi-disciplinary approach with input from neurosurgeons, neurologists, radiologists, pathologists and basic scientists. This article reviews the current literature regarding the incidence, treatment, and aetiology of TAE.

Original languageEnglish
Pages (from-to)899-908
Number of pages10
JournalJournal of Clinical Neuroscience
Volume21
Issue number6
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Epilepsy
  • Excitotoxicity
  • Glioma
  • Glutamate
  • Seizure

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