@article{0f00d47e3a884ad2a374a9bb27772ad9,
title = "Tumor-responsive dynamic nanoassemblies for targeted imaging, therapy and microenvironment manipulation",
abstract = "The recent designs of dynamic nanoassemblies exploiting the tumor-targeting properties have received increasing attention for tumor imaging and therapy due to their tumor-specific delivery and enhanced antitumor efficacy. However, these designs are mainly focused on the macroscopic tumor therapeutic effect, while the nano-bio interactions in the tumor microenvironment (TME) remain poorly understood. This review aims to provide an overview of the development of tumor-responsive nanoassemblies towards the imaging, therapy and TME modulation in the tumor site. The tumor biology leading to TME formation and the potential TME properties for the practicable design of tumor-targeting nanoassemblies has been outlined. Furthermore, the various approaches for TME modification and the realization via dynamic nanoassemblies for enhanced tumor therapy were reviewed. Lastly, the prospects of these methods were briefly discussed. These strategies may inspire the development of new combinational cancer therapeutics.",
keywords = "Controlled delivery, Dynamic nanoassembly, TME modulation, Tumor targeting, Tumor therapy",
author = "Low, {Liang Ee} and Jiahe Wu and Jiyoung Lee and Tey, {Beng Ti} and Goh, {Bey Hing} and Jianqing Gao and Fangyuan Li and Daishun Ling",
note = "Funding Information: This work was supported by National Key Research and Development Program of China (2016YFA0203600), the National Natural Science Foundation of China (31822019, 51703195, 91859116), the One Belt and One Road International Cooperation Project from the Key Research and Development Program of Zhejiang Province (2019C04024), the 2019 International Postdoctoral Exchange Fellowship Program, the National Science & Technology Major Project ?Key New Drug Creation and Manufacturing Program?, China (2018ZX09711002), the Fundamental Research Funds for the Central Universities (2019XZZX004-15), the Zhejiang Provincial Natural Science Foundation of China (LGF19C100002). We would like to thank the authors of the primary studies. Funding Information: This work was supported by National Key Research and Development Program of China ( 2016YFA0203600 ), the National Natural Science Foundation of China ( 31822019 , 51703195 , 91859116 ), the One Belt and One Road International Cooperation Project from the Key Research and Development Program of Zhejiang Province ( 2019C04024 ), the 2019 International Postdoctoral Exchange Fellowship Program, the National Science & Technology Major Project “ Key New Drug Creation and Manufacturing Program ”, China ( 2018ZX09711002 ), the Fundamental Research Funds for the Central Universities ( 2019XZZX004-15 ), the Zhejiang Provincial Natural Science Foundation of China ( LGF19C100002 ). We would like to thank the authors of the primary studies. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = aug,
day = "10",
doi = "10.1016/j.jconrel.2020.05.014",
language = "English",
volume = "324",
pages = "69--103",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier BV",
}
