Tumor Lysis Syndrome

Gareth P. Gregory; Jake Shortt

doi:10.1007/978-3-319-31738-0_76-1

Tumor Lysis Syndrome

Gareth P. Gregory, Jake Shortt

Medicine Monash Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Abstract

Tumor lysis syndrome refers to the laboratory and clinical results of rapid breakdown of high volumes of malignant cells. Significant electrolyte disturbances, particularly hyperkalemia, hypocalcemia, and hyperphosphatemia, in tandem with severe hyperuricemia, are disease hallmarks. The most significant clinical sequelae of these disturbances include life-threatening cardiac arrhythmias, sudden death, seizures, and renal failure due to precipitation of uric acid or calcium phosphate in the renal tubules.

Original language	English
Title of host publication	Textbook of Palliative Care
Editors	Roderick Duncan MacLeod, Lieve van den Block
Place of Publication	Cham
Publisher	Springer
Number of pages	15
ISBN (Electronic)	9783319317380
DOIs	https://doi.org/10.1007/978-3-319-31738-0_76-1
Publication status	Published - 2018

Access to Document

10.1007/978-3-319-31738-0_76-1

Cite this

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title = "Tumor Lysis Syndrome",

abstract = "Tumor lysis syndrome refers to the laboratory and clinical results of rapid breakdown of high volumes of malignant cells. Significant electrolyte disturbances, particularly hyperkalemia, hypocalcemia, and hyperphosphatemia, in tandem with severe hyperuricemia, are disease hallmarks. The most significant clinical sequelae of these disturbances include life-threatening cardiac arrhythmias, sudden death, seizures, and renal failure due to precipitation of uric acid or calcium phosphate in the renal tubules.",

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N2 - Tumor lysis syndrome refers to the laboratory and clinical results of rapid breakdown of high volumes of malignant cells. Significant electrolyte disturbances, particularly hyperkalemia, hypocalcemia, and hyperphosphatemia, in tandem with severe hyperuricemia, are disease hallmarks. The most significant clinical sequelae of these disturbances include life-threatening cardiac arrhythmias, sudden death, seizures, and renal failure due to precipitation of uric acid or calcium phosphate in the renal tubules.

AB - Tumor lysis syndrome refers to the laboratory and clinical results of rapid breakdown of high volumes of malignant cells. Significant electrolyte disturbances, particularly hyperkalemia, hypocalcemia, and hyperphosphatemia, in tandem with severe hyperuricemia, are disease hallmarks. The most significant clinical sequelae of these disturbances include life-threatening cardiac arrhythmias, sudden death, seizures, and renal failure due to precipitation of uric acid or calcium phosphate in the renal tubules.

U2 - 10.1007/978-3-319-31738-0_76-1

DO - 10.1007/978-3-319-31738-0_76-1

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