TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function

K. Yadava, A. Sichelstiel, I. F. Luescher, L. P. Nicod, N. L. Harris, B. J. Marsland

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Thymic stromal lymphopoietin (TSLP) is a mucosal tissue-associated cytokine that has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Although TSLP is also produced upon viral infection in vitro, the role of TSLP in antiviral immunity is unknown. In this study we report a novel role for TSLP in promoting viral clearance and virus-specific CD8+ T-cell responses during influenza A infection. Comparing the immune responses of wild-type and TSLP receptor (TSLPR)-deficient mice, we show that TSLP was required for the expansion and activation of virus-specific effector CD8+ T cells in the lung, but not the lymph node. The mechanism involved TSLPR signaling on newly recruited CD11b+ inflammatory dendritic cells (DCs) that acted to enhance interleukin-15 production and expression of the costimulatory molecule CD70. Taken together, these data highlight the pleiotropic activities of TSLP and provide evidence for its beneficial role in antiviral immunity.

Original languageEnglish
Pages (from-to)83-92
Number of pages10
JournalMucosal Immunology
Volume6
Issue number1
DOIs
Publication statusPublished - 1 Jan 2013
Externally publishedYes

Cite this

@article{9c9dab15b35e4328b116aefa729f77d2,
title = "TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function",
abstract = "Thymic stromal lymphopoietin (TSLP) is a mucosal tissue-associated cytokine that has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Although TSLP is also produced upon viral infection in vitro, the role of TSLP in antiviral immunity is unknown. In this study we report a novel role for TSLP in promoting viral clearance and virus-specific CD8+ T-cell responses during influenza A infection. Comparing the immune responses of wild-type and TSLP receptor (TSLPR)-deficient mice, we show that TSLP was required for the expansion and activation of virus-specific effector CD8+ T cells in the lung, but not the lymph node. The mechanism involved TSLPR signaling on newly recruited CD11b+ inflammatory dendritic cells (DCs) that acted to enhance interleukin-15 production and expression of the costimulatory molecule CD70. Taken together, these data highlight the pleiotropic activities of TSLP and provide evidence for its beneficial role in antiviral immunity.",
author = "K. Yadava and A. Sichelstiel and Luescher, {I. F.} and Nicod, {L. P.} and Harris, {N. L.} and Marsland, {B. J.}",
year = "2013",
month = "1",
day = "1",
doi = "10.1038/mi.2012.50",
language = "English",
volume = "6",
pages = "83--92",
journal = "Mucosal Immunology",
issn = "1935-3456",
publisher = "Nature Publishing Group",
number = "1",

}

TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function. / Yadava, K.; Sichelstiel, A.; Luescher, I. F.; Nicod, L. P.; Harris, N. L.; Marsland, B. J.

In: Mucosal Immunology, Vol. 6, No. 1, 01.01.2013, p. 83-92.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function

AU - Yadava, K.

AU - Sichelstiel, A.

AU - Luescher, I. F.

AU - Nicod, L. P.

AU - Harris, N. L.

AU - Marsland, B. J.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Thymic stromal lymphopoietin (TSLP) is a mucosal tissue-associated cytokine that has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Although TSLP is also produced upon viral infection in vitro, the role of TSLP in antiviral immunity is unknown. In this study we report a novel role for TSLP in promoting viral clearance and virus-specific CD8+ T-cell responses during influenza A infection. Comparing the immune responses of wild-type and TSLP receptor (TSLPR)-deficient mice, we show that TSLP was required for the expansion and activation of virus-specific effector CD8+ T cells in the lung, but not the lymph node. The mechanism involved TSLPR signaling on newly recruited CD11b+ inflammatory dendritic cells (DCs) that acted to enhance interleukin-15 production and expression of the costimulatory molecule CD70. Taken together, these data highlight the pleiotropic activities of TSLP and provide evidence for its beneficial role in antiviral immunity.

AB - Thymic stromal lymphopoietin (TSLP) is a mucosal tissue-associated cytokine that has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Although TSLP is also produced upon viral infection in vitro, the role of TSLP in antiviral immunity is unknown. In this study we report a novel role for TSLP in promoting viral clearance and virus-specific CD8+ T-cell responses during influenza A infection. Comparing the immune responses of wild-type and TSLP receptor (TSLPR)-deficient mice, we show that TSLP was required for the expansion and activation of virus-specific effector CD8+ T cells in the lung, but not the lymph node. The mechanism involved TSLPR signaling on newly recruited CD11b+ inflammatory dendritic cells (DCs) that acted to enhance interleukin-15 production and expression of the costimulatory molecule CD70. Taken together, these data highlight the pleiotropic activities of TSLP and provide evidence for its beneficial role in antiviral immunity.

UR - http://www.scopus.com/inward/record.url?scp=84871033436&partnerID=8YFLogxK

U2 - 10.1038/mi.2012.50

DO - 10.1038/mi.2012.50

M3 - Article

VL - 6

SP - 83

EP - 92

JO - Mucosal Immunology

JF - Mucosal Immunology

SN - 1935-3456

IS - 1

ER -