Trying to remember: Immunological B cell memory to malaria

Lars Hviid, Lea Barfod, Freya J I Fowkes

Research output: Contribution to journalReview ArticleOtherpeer-review

26 Citations (Scopus)

Abstract

In areas with stable transmission of Plasmodium falciparum parasites, even partially-protective immunity to malaria is acquired only after years of exposure and several infections. It has long been speculated that malaria parasites are directly able to undermine the establishment and maintenance of immunological memory, and that the often transient antibody responses to this parasite are evidence of such a dysfunction. We propose that long-lived antibody responses may not always be a prerequisite for protection, and that antibody longevity varies in an exposure- and age-dependent manner.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalTrends in Parasitology
Volume31
Issue number3
DOIs
Publication statusPublished - 1 Mar 2015

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