Tropical plant extracts as potential antihyperglycemic agents

Thamilvaani Manaharan, Uma Devi Palanisamy, Hwee Ming Cheng

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    27 Citations (Scopus)

    Abstract

    Preliminary investigations on 14 plant extracts (obtained by ethanolic and aqueous extraction) identified those having high antioxidant and a significant total phenolic content. Antihyperglycemic, ??-amylase and ??-glucosidase inhibition activities were also observed. A correlation between the antihyperglycemic activity, total phenolic content and antioxidant (DPPH scavenging) activity was established. To further substantiate these findings, the possibility of tannins binding non-specifically to enzymes and thus contributing to the antihyperglycemic activity was also investigated. Our study clearly indicated that the antihyperglycemic activity observed in the plant extracts was indeed not due to non-specific tannin absorption.
    Original languageEnglish
    Pages (from-to)5915 - 5923
    Number of pages9
    JournalMolecules
    Volume17
    Issue number5
    DOIs
    Publication statusPublished - 2012

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