Triacylglycerol lipases and metabolic control: Implications for health and disease

Matthew James Watt, Lawrence L Spriet

Research output: Contribution to journalArticleOther

55 Citations (Scopus)

Abstract

Fatty acids derived from the hydrolysis of adipose tissue and skeletal muscle triacylglycerol (TG) are an important energy substrate at rest and during physical activity. This review outlines the identification of the new TG lipase, adipose triglyceride lipase, the current understanding of how cellular TG lipases are regulated, and the implications for understanding the integrated control of TG lipolysis. Further, this review outlines recent advances that propose a revised role for TG lipases in cellular function, metabolic homeostasis and disease prevention.
Original languageEnglish
Pages (from-to)E162 - E168
Number of pages7
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume299
Issue number2
DOIs
Publication statusPublished - 2010

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