TY - JOUR
T1 - Triacylglycerol lipases and metabolic control: Implications for health and disease
AU - Watt, Matthew James
AU - Spriet, Lawrence L
PY - 2010
Y1 - 2010
N2 - Fatty acids derived from the hydrolysis of adipose tissue and skeletal muscle triacylglycerol (TG) are an important energy substrate at rest and during physical activity. This review outlines the identification of the new TG lipase, adipose triglyceride lipase, the current understanding of how cellular TG lipases are regulated, and the implications for understanding the integrated control of TG lipolysis. Further, this review outlines recent advances that propose a revised role for TG lipases in cellular function, metabolic homeostasis and disease prevention.
AB - Fatty acids derived from the hydrolysis of adipose tissue and skeletal muscle triacylglycerol (TG) are an important energy substrate at rest and during physical activity. This review outlines the identification of the new TG lipase, adipose triglyceride lipase, the current understanding of how cellular TG lipases are regulated, and the implications for understanding the integrated control of TG lipolysis. Further, this review outlines recent advances that propose a revised role for TG lipases in cellular function, metabolic homeostasis and disease prevention.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20071561
U2 - 10.1152/ajpendo.00698.2009
DO - 10.1152/ajpendo.00698.2009
M3 - Article
SN - 0193-1849
VL - 299
SP - E162 - E168
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
IS - 2
ER -